Pediatric chronic nonbacterial osteomyelitis of the mandible: Seattle Children ’s hospital 22-patient experience

Studies evaluating treatment responses for chronic nonbacterial osteomyelitis (CNO) are lacking. We aimed to measure and compare response rates of medical treatments, time to response of medical treatments amo...
Source: Pediatric Rheumatology - Category: Rheumatology Authors: Tags: Research article Source Type: research

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AbstractAutoinflammatory diseases are a family of disorders characterized by aberrant stimulation of inflammatory pathways without involvement of antigen-directed autoimmunity. They can be further divided in monogenic and polygenic types. Those without an identified genetic mutation are known as polygenic and include systemic-onset juvenile idiopathic arthritis, idiopathic recurrent acute pericarditis, Beh çet syndrome, chronic recurrent multifocal osteomyelitis and inflammatory bowel disease among others. Autoinflammatory diseases are characterized by recurrent flares or persistent systemic inflammation and fever, ...
Source: Pediatric Radiology - Category: Radiology Source Type: research
There are currently no robust methods for accurately localizing the infection focus of osteomyelitis. Accumulation of fluorodeoxyglucose (FDG) is nonspecific, and it is well-known that it can indicate inflammatory cells and sites of inflammation, and its effectiveness in detecting osteomyelitis has been reported recently. However, the optimal cut-off value for the Standardized Uptake Value (SUV) in detecting the focus of osteomyelitis through 18F-FDG-PET/CT is not known. We investigated the optimal SUV cut-off values using 18F-FDG positron emission tomography (PET)computed tomography (CT) to visualize the infection focus o...
Source: Injury - Category: Orthopaedics Authors: Tags: Regular Papers Source Type: research
ConclusionApproximately three-quarters of discitis-osteomyelitis pathogens will be identified by biopsy sample culture by 3 days after CT-guided biopsy. This finding should be considered if planning for a repeat biopsy in the setting of a negative microbiology culture.
Source: Skeletal Radiology - Category: Radiology Source Type: research
Publication date: Available online 13 February 2020Source: The Journal of Foot and Ankle SurgeryAuthor(s): Easton C. Ryan, Peter A. Crisologo, Javier La Fontaine, Dane K. Wukich, Orhan K. Oz, Kavita Bhavan, Lawrence A. LaveryAbstractThe aim of this study was to report clinical outcomes of moderate and severe foot infections in patients without diabetes. Medical records of 88 nondiabetic patients with foot infections treated at a safety net hospital were retrospectively reviewed. Patients were grouped by the presence of soft-tissue infection (STI) or osteomyelitis (OM). The diagnosis of OM was determined by positive bone cu...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Vertebral osteomyelitis can be attributed to many factors including immunosuppression, diabetes, malignancy, collagen disease, periodontal disease, open fractures, and endoscopic procedures. Anaerobic bacteria...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
Publication date: June 2020Source: Interdisciplinary Neurosurgery, Volume 20Author(s): Adrian Kelly, Aftab Younus, Patrick LekgwaraAbstractOsteopetrosis is a metabolic bone disease resulting in skeletal hyper-sclerosis. Three major genetic subtypes of the disease are phenotypically expressed into three distinguishable forms of the disease, each dictating specific management. Autosomal recessive “severe” osteopetrosis occurs secondary to defective osteoclastic resorption of immature bone. Regarding the neurosurgical considerations in this group cranial concerns rather than spinal symptoms often predominate. Visu...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Publication date: Available online 7 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Mercedes Gonzalez Moreno, Maria Eugenia Butini, Elena Maryka Maiolo, Laura Sessa, Andrej TrampuzAbstractBioactive glass (BAG) is a synthetic bone substitute with intrinsic antimicrobial properties, used for bone defect filling. We evaluated the antimicrobial activity of two formulations of BAG S53P4 against representative pathogens of osteomyelitis: Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli and Candida albicans. Antimicrobial activity of BAG S53P4 was assessed by isothe...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Authors: Seddon K, Low C PMID: 32027641 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
AbstractSkull base osteomyelitis (SBO) is a potentially life-threatening inflammation of cranial base bony structures of variable origin. Criteria for diagnosis and treatment are still controversial. Demographics, predisposing factors, symptoms, imaging, and clinical, laboratory, histological, and microbiological data of patients managed for SBO at the University Hospital of Brescia (ASST Spedali Civili) between 2002 and 2017 were retrospectively reviewed. Patients were included in different etiological groups. The topographic distribution of magnetic resonance (MR) abnormalities was recorded on a bi-dimensional model of s...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
We present the case of an 89-year-old man with Serratia marcescens urosepsis with multifocal end-organ infection on 18F-FDG PET/CT including aortitis, splenic abscess, septic arthritis, thoracolumbar discitis-osteomyelitis, and culture-confirmed bilateral endogenous endophthalmitis. Endophthalmitis-related intraconal ocular space uptake was clearly distinguishable from normal conal space extraocular muscle activity. Although sepsis responded to treatment, endophthalmitis led to complete vision loss. This case report presents PET/CT description of a rare and difficult-to-treat Serratia marcescens endogenous endophthalmitis,...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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