Use of Salvage Surgery or Stereotactic Radiosurgery for Multiply Recurrent Skull Base Chordomas: A Single-Institution Experience and Review of the Literature

Conclusion Refractory skull base chordomas present a challenging treatment dilemma. Repeat surgical resection or SRS seems to provide adequate salvage therapy that is well-tolerated when treated at a tertiary center offering multimodality care. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part B: Skull Base - Category: Neurosurgery Authors: Tags: Original Article Source Type: research

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The complex mechanisms underlying migraine are not entirely understood. It has been suggested that descending endogenous pain modulation is an important contributing factor, although research is controversial. A frequently used method to quantify the inhibitory pain modulation system is offset analgesia (OA), defined as a disproportionally large decrease in pain perception in response to a small decrease of painful stimulation. The aim of this study is to evaluate the OA response in patients with migraine and healthy controls, measured at the forehead (trigeminal, V1) and forearm (extratrigeminal). Patients with episodic m...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Authors: Gray M, Adamson MM, Thompson RC, Kapphahn KI, Han S, Chung JS, Harris OA Abstract Primary Objective: Research focused on mild traumatic brain injury in active military and veteran populations details the psychological, neurological and functional outcomes of mTBI, in a primarily male (~95%) cohort. This may misrepresent female symptoms and outcomes. Here we assess for genuine sex differences in symptom presentation and functional outcomes.Research Design: We used matched pairs to preclude potential sex bias in outcome data.Methods and Procedures: We matched 49 female/male pairs on; 1) mechanism of injury, ...
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
We describe three cases of lymphoma in which lymphoma mimicked other diseases causing neurological dysfunction, specifically sarcoidosis, vasculitis and infection respectively. Case 1 was a 66-year-old man with subacute progressive diplopia and gait disturbance and investigations revealing a supratentorial para-falcine soft tissue lesion, mid-thoracic cord enhancement and right axillary mass and an elevated serum ACE. Right axillary mass core biopsy was diagnostic of Burkitt lymphoma. Case 2 was a 50-year-old man with several weeks of constitutional symptoms and development of lower limb weakness and numbness, urinary rete...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
A 40-year-old male patient was admitted to the emergency department for persistent severe headache unrelieved by paracetamol. He had no medical history but reported asthenia and weight loss (2 kg) over the previous 3 weeks. At admission, blood pressure was 120/80 mm  Hg and physical examination was unremarkable. Laboratory blood tests showed: serum creatinine 1.7 mg/dl, sodium 141 mmol/l, calcium 9.2 mg/dl, C-reactive protein 6 mg/l, leucocytes 11520/mm3, neutrophils 9230/mm3, lymphocytes 1090/mm3, and hemoglobin 13.6 g/dl.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
We report an increased burden of rare variants in one CpG island and three polycomb group response elements near four migraine risk loci. We found that the association is independent of the common risk variants in the loci. The regulatory regions are suggested to affect different genes than those originally tagged by the index SNPs of the migraine loci. Families with familial clustering of migraine have an increased burden of rare variants in regulatory regions near known migraine risk loci, with effects that are independent of the variants in the loci. The possible regulatory targets suggest different genes than those ori...
Source: Neurogenetics - Category: Genetics & Stem Cells Source Type: research
ConclusionAseptic meningitis may be an atypical phenotype of NMOSD flare that is easily confused with specific infection. Comprehensive evaluation to exclude an infective etiology and enable accurate diagnosis and timely immunotherapy are critical to prognosis.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Do persons with specific personality traits exhibit a better response to migraine treatment with onabotulinumtoxin A?Headache
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
Since we are living in a time of extremely high statistical occurrences of childhood anxiety, depression and even suicide (which is happening at even younger ages), we need to look at the causes that are behind these difficult challenges that children, teens and young adults are facing today. Whether it be parental influences, interactions with abusive outsiders, school bullying, or something else, mental illnesses are growing at a rampant rate.  When mental illness is not alleviated, it can create C-PTSD (compound or complex PTSD), so it’s critical to reverse it early. What sometimes keeps the underlying factor...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Children and Teens Parenting Trauma adverse childhood experiences Childhood Trauma Source Type: blogs
Conclusion: Post-herpetic anti-NMDAr AIE could arise several months after infection. Clinicians must be aware of this possibility, particularly if cognitive and/or psychiatric symptoms occurred after a remitting period. In our two cases, only rituximab was associated with clinical improvement.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Recently, clinicians have been using repetitive transcranial magnetic stimulation (rTMS) for treating various pain conditions. This systematic narrative review aimed to examine the use and efficacy of rTMS for controlling various pain conditions. A PubMed search was conducted for articles that were published until June 7, 2019 and used rTMS for pain alleviation. The key search phrase for identifying potentially relevant articles was (repetitive transcranial magnetic stimulation AND pain). The following inclusion criteria were applied for article selection: (1) patients with pain, (2) rTMS was applied for pain management, a...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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