The role of diabetes mellitus on the thrombus composition in patients with acute ischemic stroke.

CONCLUSION: Clots in diabetic patients had more fibrin and fewer erythrocyte components compared with patients without diabetes mellitus, while hyperglycemia on admission did not show association with clot composition. Further studies are needed to confirm these results. PMID: 31924102 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - Category: Radiology Tags: Interv Neuroradiol Source Type: research

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WEST NILE VIRUS INFECTION WITH NEUROLOGICAL DISORDERS: A CASE REPORT AND A BRIEF REVIEW OF THE SITUATION IN BULGARIA. Acta Clin Croat. 2019 Sep;58(3):546-549 Authors: Baymakova M, Christova I, Panayotova E, Trifonova I, Chobanov A, Daskalov I, Popov GT, Plochev K Abstract A case of a 66-year-old man with West Nile neuroinvassive disease manifested with fever, weakness, fatigue, consciousness disorders and underlying diabetes mellitus type 2 and cardiovascular diseases is presented. Laboratory data showed elevated erythrocyte sedimentation rate and fibrinogen. Serological tests revealed West Nile virus ...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
We describe a case of aggressive progression of TA in an infant. This child was the youngest to be affected with the disease as reported in the literature. A 3.5-month-old boy presented with cyanosis of both legs, tachycardia and antithrombin III deficiency. Computed tomography angiography (CTA) revealed thrombosis of distal aorta and both iliac arteries. Thrombectomy was performed at the level of both common femoral arteries. In addition, thigh amputation of the left leg had to be performed. TA was diagnosed postmortem with thrombosis of the distal aorta, its branches and upper mesenteric artery which was not occluded on ...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
This study has been carried out to examine the effect of SSF by Rhizopus oryzae on the bioactive content, bioactivity, bioaccessibility and bioavailability of 4 different varieties of rice bran. In vitro digestion with dialysis was carried out to assess the bioavailability and bioaccessibility of rice bran bioactives. Methanolic extracts and digested fractions of fermented and unfermented rice brans were analyzed for total phenolic (TPC), flavonoid (TF), carotenoid (TC), and total anthocyanin content (TAC). Additionally, antioxidant activity, anti-inflammatory property and the anti-diabetic property was also evaluated. The...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 23 January 2020Source: Life SciencesAuthor(s): Irshad Ahmad, Muddasarul HodaAbstractResveratrol is an important phenolic phytochemical from the therapeutic perspective. It has therapeutic impacts over wide range of diseases, especially the ones related to oxidative stress. Resveratrol, being primarily a potent anti-oxidant phytochemical, has significant impact against major diseases as inflammatory disorders, diabetes, and cancer. In the current review article, we intend to highlight the molecular aspects of the mechanism of action of resveratrol against major diabetic implications, namel...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we investigated different bioactive compounds in marine resources that may be potentially useful in treating or managing diabetes, as well as describe the various therapeutic mechanisms affecting diabetes and its complications, including inhibition of α-amylase, α-glucosidase, β -glucosidase, glycogen synthase kinase 3β (GSK-3β), lipase, aldose reductase, protein tyrosine phosphatases 1B (PTP1B) and dipeptidyl peptidase IV   (DPP-4), prevention of insulin resistance, increased phosphorylation of the AMP-activated protein kinase (AMPK) and adjusting the metabolism of glucose ...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Publication date: Available online 23 January 2020Source: PeptidesAuthor(s): Keita Sasaki, Sebok Kumar Halder, Hayato Matsunaga, Hiroshi UedaAbstractProthymosin alpha (ProTα)-mimetic hexapeptide (amino acid: NEVDQE, P6Q) inhibits cerebral or retinal ischemia-induced behavioral, electrophysiological and histological damage. P6Q also abolishes cerebral hemorrhage induced by ischemia with tissue plasminogen activator (tPA). In the present study we examined the beneficial effects of P6Q on other post-stroke prognostic psychology-related symptoms, which obstruct the motivation toward physical therapy. Intravenous (i.v.) a...
Source: Peptides - Category: Biochemistry Source Type: research
This study was done in a newly available large-scale claims database, which may differ from other population databases, by it size and exhaustiveness•The methods elaborate on standard high-dimensional propensity scores as adapted to this claims databaseGraphical abstract
Source: MethodsX - Category: Science Source Type: research
CONCLUSION: Use of the CFTR modulator lumacaftor/ivacaftor was associated with significantly lower hepatic steatosis. No association between CFRD and hepatic steatosis was found in this cohort. PMID: 31966908 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Publication date: Available online 23 January 2020Source: Genes &DiseasesAuthor(s): S. Mohana Devi, I. Mahalaxmi, J. Kaavya, V. Chinnkulandhai, V. BalachandarAbstractEpigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism. They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression. DNA methylation is the earliest discovered epigenetic alteration. In this review, we try to examine the role of DNA methylation and histone...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
ConclusionsThis retrospective study showed that TARE therapy resulted in minimal toxicity in patients with HBV-derived HCC. Patients with CP A or BCLC A disease had superior survival outcomes compared to patients with CP B and BCLC B/C disease. These findings suggest that TARE is a viable treatment option for certain patient groups with HCC tumors secondary to HBV infection.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
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