Nanomaterials to avoid and destroy protein aggregates

Publication date: Available online 11 January 2020Source: Nano TodayAuthor(s): Félix Sauvage, Joost Schymkowitz, Frederic Rousseau, Bela Z. Schmidt, Katrien Remaut, Kevin Braeckmans, Stefaan C. De SmedtAbstractAggregation of proteins is involved in many disorders. Besides amyloid fibrils, which mostly form in the brain, other kind of protein aggregates can lead, for example, to clots in the blood or floaters in the vitreous of the eye. This review aims to overview on how nanomaterials could be employed to avoid and destroy most diverse protein aggregates. Indeed, thanks to their recognized versatility, (stimuli-responsive) nanomaterials may offer attractive features against harmful protein aggregates. However, despite the many conceptually interesting strategies it appears that most important information on both the in vivo efficacy and safety of nanotechnology based prevention or destruction of protein aggregates, which is highly needed to pave the way to clinically relevant therapies, remains missing.Graphical abstract
Source: Nano Today - Category: Nanotechnology Source Type: research