Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides.

Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides.
Eur J Med Chem. 2013 Aug 23;69C:174-181
Authors: Xu Y, Chen X, Zhu D, Liu Y, Zhao Z, Jin L, Liu C, Lei P
Abstract
A practicable method of introducing a side chain to the C-4' position of 5-O-desosamine in the 14-membered ketolides was developed. And using this method, a series of novel modified 5-O-mycaminose ketolides were synthesized. These ketolides containing 5-O-4'-carbamate mycaminose were evaluated for their in vitro antibacterial activities against some respiratory pathogens. 15b and 18e showed comparable activity to telithromycin and clarithromycin.
PMID: 24021890 [PubMed - as supplied by publisher]

Source: European Journal of Medicinal Chemistry - August 23, 2013 Category: Chemistry Authors: Xu Y, Chen X, Zhu D, Liu Y, Zhao Z, Jin L, Liu C, Lei P Tags: Eur J Med Chem Source Type: research