The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy.

The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy. Trends Neurosci. 2020 Jan 06;: Authors: Christ MG, Clement AM, Behl C Abstract Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated with defective autophagy and its pharmacological activation induces autophagic activity. PMID: 31918966 [PubMed - as supplied by publisher]
Source: Trends in Neurosciences - Category: Neuroscience Authors: Tags: Trends Neurosci Source Type: research