Experimental validation of recommended < i > msr < /i > -correction factors for the calibration of Leksell Gamma Knife < sup > ® < /sup > Icon ™ unit following IAEA TRS-483.

Experimental validation of recommended <i>msr</i>-correction factors for the calibration of Leksell Gamma Knife^® Icon™ unit following IAEA TRS-483.
Phys Med Biol. 2020 Jan 08;:
Authors: Mirzakhanian L, Sarfehnia A, Seuntjens J
Abstract
Currently, the American Association of Physicists in Medicine (AAPM) TG-21 is the conventional protocol currently used for the calibration of the Leksell Gamma Knife (LGK) (despite the publication of the AAPM TG-51 protocol). However, this protocol is based on the air-kerma standards requiring an elaborate conversion process resulting in an increase in the possibility of errors in the clinic. The International Atomic Energy Agency (IAEA) Technical Reports Series (TRS)-483 Code of Practice (CoP) provides new recommendations on the dosimetry of small static fields and correction factor data for the calibration of the LGK unit. The purpose of this study is to experimentally validate previously calculated kfmsr,frefQmsr,Q0factors for the calibration of the LGK Perfexion/Icon unit in the context of the TRS-483 protocol. An experimental comparison between three protocols (TG-51, TG-21 and TRS-483 with the aforementioned correction factors) for calibration of the LGK unit is provided. Dose rate measurements were performed on a LGK Icon unit using three ionization chambers and three phantoms with different orientations of the chambers with respect to the LGK unit. The dose...

Source: Physics in Medicine and Biology - January 7, 2020 Category: Physics Authors: Mirzakhanian L, Sarfehnia A, Seuntjens J Tags: Phys Med Biol Source Type: research