Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells

In conclusion, Id proteins, and particularly Id1 and Id3, are critical downstream effectors of BMP signaling in PASMCs. Loss of BMPR-II function reduces the induction of Id genes in PASMCs, Id1, and Id3 regulate the proliferation of PASMCs via cell cycle inhibition, an effect that may be exacerbated by inflammatory stimuli.

Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2013 Category: Respiratory Medicine Authors: Yang, J., Li, X., Li, Y., Southwood, M., Ye, L., Long, L., Al-Lamki, R. S., Morrell, N. W. Tags: ARTICLES Source Type: research