Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4

ConclusionsWe have detected neoantigen-targeted reactivity by autologous T cells in mismatch repair-proficient colorectal cancers of the CMS4 subtype. These findings warrant the development of specific immunotherapeutic strategies that selectively boost the activity of neoantigen-specific T cells and target the TGF- β pathway to reinforce T cell reactivity in this patient group.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research