How do we Treat Inflammatory Bowel Diseases to Aim For Endoscopic Remission?

Crohn ’s disease and ulcerative colitis are heterogeneous conditions which may manifest with one or more of a constellation of abnormal symptoms, elevated biomarkers, and/or objective evidence of inflammation on endoscopic or cross-sectional evaluation. Whilst resolution of symptoms and restoration of q uality of life is the primary goal for patients following a disease flare, there may be discordance between resolution of symptoms, biomarkers, and endoscopy. Increased emphasis is placed on the achievement of endoscopic remission, given it is associated with improved outcomes and reduction in hospi talization and surgeries.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research

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The subtype of inflammatory bowel disease (IBD) is often not known at index colonoscopy and examining for perianal disease (PAD) can assist in establishing the diagnosis. PAD is common in Crohn ’s disease (CD) but can also be seen in patients with ulcerative colitis (UC) in the form of fissures, abscesses and fistulae. Absence of perianal symptoms does not exclude PAD. Performing a routine perianal examination in a busy outpatient setting is not ideal and the endoscopy suite may be more appropriate.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Disease Activity Assessment Source Type: research
Conclusions: Depression is associated with prolonged LOS in pediatric patients with IBD, even when controlling for gastrointestinal disease severity. Future research evaluating the efficacy of standardized depression screening and early intervention may be beneficial to improving inpatient outcomes in this population.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research
Conclusions: Anorectal function is impaired in IBD patients with perianal disease. Fecal incontinence correlates with poorer quality of life. Anorectal manometry and ultrasonography are useful tools for evaluating IBD patients. PMID: 31625422 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
Conclusions: Standard FC-ELISA for FC evaluation is more reliable predictor of mucosal healing than the FC-IBDoc in paediatric patients with inflammatory bowel disease. The cut-off values for both tests were incongruous.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research
Authors: El-Salhy M, Gilja OH, Hatlebakk JG Abstract Irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD) overlap. It is not clear whether GERD is caused by non‑erosive esophagitis, or erosive esophagitis. The Rome criteria are not widely used for the diagnosis of IBS in the clinic. In total, 1,489 IBS patients without red flags were included in the present retrospective study. They comprised of 1,331 females and 158 males with a mean age of 51 years. The diagnosis of IBS was verified by endoscopic and histopathological examinations. Whereas erosive esophagitis occurred in 97% of patient...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Patients with longstanding inflammatory bowel disease (IBD) (ulcerative colitis [UC] or colonic Crohn ’s disease [CD]) have an increased risk of colorectal cancer (CRC). International consensuses recommend description of visible lesions according to the Paris classification, although little is known about the correlation between each type of lesion and the risk of dysplasia.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday abstract Source Type: research
The relationship between inflammatory bowel disease (IBD) and gallstones has been recognized. There have been few studies comparing the incidence of cholelithiasis bewteen ulcerative colitis and Crohn ’s disease. The aim of this study was to evaluate the incidence and risk factors of cholelithiasis in IBD patients.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday abstract Source Type: research
Inflammatory bowel diseases (IBD) include two major forms of chronic intestinal disorders: Crohn ’s disease (CD) and ulcerative colitis (UC). CD can be associated with intestinal granulomas, strictures, fistulas, and transmural inflammation. A single gold standard for the diagnosis of CD is not available. The diagnosis is confirmed by clinical evaluation and a combination of endoscopic, histo logical, radiological, and/or biochemical investigations. Serum protein profiling of CD was investigated in order to improve the comprehension of the pathologic mechanisms and to support the difficult diagnostic procedures curre...
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday abstract Source Type: research
Patients with ulcerative colitis (UC) and Crohn's disease (CD) have a higher risk of colorectal cancer (CRC) than the general population. Dysplasia is the precursor lesion of CRC and guidelines recommend dye-spraying chromoendoscopy (DCE) for its surveillance. We aimed to compare the efficacy of the different endoscopic image enhancement methods for dysplasia surveillance in patients with UC and CD.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday abstract Source Type: research
Total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the procedure of choice for patients with medically-refractory ulcerative colitis (UC) and UC with dysplasia. Strictures and fistulae may develop within the pouch or pre-pouch ileum, most commonly due to post-surgical complications or Crohn ’s disease of the pouch. Both issues lead to significant morbidity and occasional pouch failure, often requiring pouch redo or excision. Our aim was to assess minimally invasive endoscopic approaches for management of pouch fistulae and strictures as primary or rescue intervention in patients at h igh risk for pouch failure.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday abstract Source Type: research
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