Analysis of hemodynamics and angiogenic response to ischemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats.
In this study, we investigated the usefulness of Spontaneously Diabetic Torii Leprfa (SDT fatty) rats, a new model for obese type 2 diabetes, as a new PAD animal model. We found that hindlimb blood flow in SDT fatty rats was significantly lower than that in Sprague-Dawley (SD) rats under nonischemic conditions. Furthermore, SDT fatty rats showed a significantly higher plasma nitrogen oxide level, shorter prothrombin time, and shorter activated partial thromboplastin time than SD rats. In addition, we found that the change in blood flow 7 days after induction of hindlimb ischemia and the number of Von Willebrand Factor-positive vessels in gastrocnemius muscles were significantly lower in SDT fatty rats than in SD rats. These results suggest that excess production of reactive oxygen species and coagulation activation could be involved in lower blood flow in nonischemic rats and that decreased angiogenesis could be involved in the poor recovery of blood flow in SDT fatty rats with hindlimb ischemia. Taken together, our results suggest that SDT fatty rats might be useful as a new model for PAD with metabolic syndrome. PMID: 31868944 [PubMed - as supplied by publisher]
CONCLUSIONS: The average patient is middle aged (often male) with a history of subacute back pain, sometimes presenting fever and/or neurological damage on diagnosis. Acute phase reactants are frequently raised. Diabetes mellitus, endocarditis and immunosuppressed patients may have the worst chance of a good outcome, therefore these patients should be more carefully managed (always try to obtain an imaging-guided biopsy, correct antibiotic treatment, and a functional and clinical follow-up). PMID: 32446680 [PubMed - as supplied by publisher]
TYPE 2 diabetes does not pose a threat if you keep blood sugar levels under control. Diet acts as the ultimate bulwark against high blood sugar levels and a natural green powder has been proven to lower blood sugar.
Publication date: Available online 24 May 2020Source: Canadian Journal of DiabetesAuthor(s): Jacob M. Zamora, Jason M. Kong
Does the Trump-hyped drug hydroxychloroquine have the potential to treat diabetes?
All about “blood glucose management” for diabetes: how does it work, and how can you master it?
This study, for instance, attributes a patient’s waitlist/transplant outcome to the very last dialysis facility the patient was associated with. In epidemiology speak, this means the causal inference authors are trying to draw between for-profit status and good transplant outcomes is subject to time-varying confounding. As an example, if one is seeking an association between testosterone levels and risk of a heart attack, using the last testosterone level available would be a poor way of doing this study because testosterone levels are known to vary over time. The same applies to dialysis facilities. Patie...
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Kehinde S. Olaniyi, Oluwatobi A. Amusa
Publication date: Available online 24 May 2020Source: PhytomedicineAuthor(s): Nani Wang, Pingcui Xu, Xuping Wang, Weixuan Yao, Binjie Wang, Yuanzhao Wu, Dan Shou
Derek Lowe in his Science Magazine blog asks the obvious question. Why the hell are we still conducting trials of hydroxychloroquine for Covid-19 and why are doctors giving it to people. The verdict is in. It doesn't work. On the contrary, it kills people. He discusses this paper inThe Lancet which is a retrospective observational study -- yes, yes, not a randomized controlled trial but quite compelling:[W]hen compared with mortality in the control group [i.e., people hospitalized with Covid-19 who did not receive HCQ] (9 ·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1&...
At any given time, more than a third of Americans are on a specific diet, with weight loss as a leading reason. Most are going to be disappointed, because even when successful, lost weight is frequently regained within a few months. While most weight-loss diets can help you lose weight, they may be unsuccessful over the long run for a number of reasons. Some people don’t follow their diets carefully and don’t lose much weight even from the start. Others may go off the diet entirely after a while, because it’s too restrictive or the foods aren’t appealing. Some may engage in less physical activity as...