Real-world outcomes of treatment with insulin glargine 300  U/mL versus standard-of-care in people with uncontrolled type 2 diabetes mellitus.

Conclusion: In both REACH and REGAIN, no differences in glycemic control or hypoglycemia outcomes with Gla-300 versus SoC BIs was seen over 12 months. However, the suboptimal insulin titration in REACH and REGAIN limits comparisons of outcomes between treatment arms and suggests that more titration instruction/support may be required for patients to fully derive the benefits from newer basal insulin formulations. PMID: 31865758 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
The present study was conducted to explore the stratified and joint effects of age at menopause and body mass index (BMI) with the risk of type 2 diabetes mellitus (T2DM) in Chinese rural adults.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
AbstractThe mechanisms of the diuretic effect of sodium-glucose cotransporter 2 (SGLT2) inhibitor and its predictors in heart failure (HF) patients with coexisting type 2 diabetes mellitus (T2DM) remain under investigation. A total of 40 hospitalized HF patients with T2DM (68  ± 13 years old, male gender 63%) were prospectively enrolled and received ipragliflozin at a dose of 50 mg once daily after breakfast for at least 4 consecutive days. They underwent first-morning blood and urine tests, and 24-h urine tests before and after short-term ipragliflozin therapy. D aily urine volume significan...
Source: Heart and Vessels - Category: Cardiology Source Type: research
AbstractAimThe present study aimed to evaluate the combined effect of both dose and duration of metformin therapy on vitamin B12 levels in patients with type 2 diabetes mellitus (T2D).MethodsWe recruited 2887 patients with T2D between January 2018 and November 2019 and categorized them into two groups (metformin and non-metformin users) matched for age, mean duration of diabetes, and BMI. We calculated the “Metformin Usage Index” (MUI) which was defined as the product of the dose of metformin (mg) used and its duration divided by 1000. Vitamin B12 levels were compared between the two groups, and its association...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
This study included 1,408 diabetic patients, with a mean age of 64.4±7.8 years. The average pCT decreased with renal function deterioration, with 126.0 μm ± 58.0 μm for non-CKD, 112.0 μm ± 51.2 μm for mild CKD and 71.0μm ± 22.9 μm for MS-CKD, respectively (P
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
AbstractSitagliptin attenuates left ventricular (LV) dysfunction and may improve oxygen uptake in animals. The effects of sitagliptin on oxygen uptake (VO2) and exercise hemodynamics have been unclear in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). Thirty patients with T2DM and CAD were randomized into a sitagliptin (50 mg/day) or voglibose (0.6 mg/day) group. Patients underwent maximal cardiopulmonary exercise testing. VO2 and hemodynamics were evaluated at rest, anaerobic threshold and peak exercise. Resting LV diastolic function (E ’, peak early diastolic mitral annular velocity...
Source: Heart and Vessels - Category: Cardiology Source Type: research
CONCLUSIONS These results indicate that GDLP against T2DM-induced hepatic steatosis, oxidative stress, and inflammation by improving the Nrf2/HO-1 signaling pathway in db/db mice, suggesting the GDLP may serve as an effective strategy for in fatty liver treatment. PMID: 32245940 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 4 April 2020Source: Journal of Ayurveda and Integrative MedicineAuthor(s): Naresh Kumar P, Ragavendrasamy Balakrishnan, Vibhas Kana
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
This study aimed to investig...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
Gestational diabetes mellitus (GDM) is a common complication of pregnancy associated with significant maternal and neonatal morbidities, including increased risk of pre-eclampsia, macrosomia, and subsequent type 2 diabetes.[1] In most developed countries, universal glucose testing is performed at 24-28 weeks ’ gestation to identify women with overt glucose intolerance.[2] Ideally, women at high risk of developing GDM would be identified earlier in pregnancy to facilitate preventive intervention, enhance antenatal care, and improve clinical outcomes through reduced maternal and fetal exposure to metabo lic alterations...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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