Monoclonal immunoglobulin G1 κ-type atypical antiglomerular basement membrane disease accompanied by necrotizing glomerulonephritis
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CONCLUSION: We described an atypical variant of anti-GBM disease due to monoclonal IgG1-κ. Unlike usual atypical anti-GBM disease cases, we observed crescent formation in our patient. Further investigations are needed to identify the cause of nondetectable serum anti-GBM antibodies and to describe the causal relationships between clinicopathological features and the pattern of IgG subclass and light chain in atypical anti-GBM disease.
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PMID: 31854296 [PubMed - as supplied by publisher]

Source: Clinical Nephrology - December 18, 2019 Category: Urology & Nephrology Authors: Tsuji T, Ohashi N, Sato T, Goto D, Nagata S, Matsuyama T, Naito Y, Tsuji N, Isobe S, Fujikura T, Kato A, Fujigaki Y, Shimizu A, Yasuda H Tags: Clin Nephrol Source Type: research