Radiation effects on Toxoplasma antigens: Different immune responses of irradiated intact tachyzoites or soluble antigens in experimental mice models.

Conclusions: Our data suggest that, MHCI pathway appears seem to be used by RH0.25kGy to generate cytotoxic cells while STag1.5kGy uses an MHCII pathway for B-cell memory, but both induce sufficient immune response for protection in mice without any adjuvant. Irradiation of soluble protein extracts enhances their immune response, allowing similar protection against T. gondii in mice as compared to irradiated intact parasites. PMID: 31855098 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research