Host monitoring of quorum sensing during Pseudomonas aeruginosa infection

We describe a pattern of regulation in the host by the aryl hydrocarbon receptor (AhR) that is critically dependent on qualitative and quantitative sensing of P. aeruginosa quorum. QS molecules bind to AhR and distinctly modulate its activity. This is mirrored upon infection with P. aeruginosa collected from diverse growth stages and with QS mutants. We propose that by spying on bacterial quorum, AhR acts as a major sensor of infection dynamics, capable of orchestrating host defense according to the status quo of infection.

Source: ScienceNOW - December 18, 2019 Category: Science Authors: Moura-Alves, P., Puyskens, A., Stinn, A., Klemm, M., Guhlich-Bornhof, U., Dorhoi, A., Furkert, J., Kreuchwig, A., Protze, J., Lozza, L., Pei, G., Saikali, P., Perdomo, C., Mollenkopf, H. J., Hurwitz, R., Kirschhoefer, F., Brenner-Weiss, G., Weiner, J., Os Tags: Immunology, Microbiology, Online Only r-articles Source Type: news