Infections Preceding the Development of Dercum disease
Publication date: Available online 19 December 2019Source: IDCasesAuthor(s): Karen Beltran, Rita Wadeea, Karen L. HerbstABSTRACTDercum Disease (DD) is a rare inflammatory disease of painful subcutaneous fat masses with known alterations in lymphatic vessels. DD masses vary from pearl to walnut-size or larger and occur anywhere in body fat. Signs and symptoms of DD are similar to fibromyalgia. While the etiology of DD is unknown, metabolic, autoimmune, or autosomal genetic transmission has been proposed. This series presents 7 cases where DD followed an infection either histoplasmosis, coccidioidomycosis or Lyme disease. Known changes in fat by infectious agents are reviewed. Early diagnosis and treatment of infections may prevent further damage to fat.
This study aimed to develop and characterize the physicochemical, rheological, microbiological and sensory properties of coffee flavored kefir. Kefir formulations were prepared by adding different amounts of skim milk powder, instant coffee and refined sugar into the fermented milk. The optimal formulation was determined using the desirability function and subjected to Temporal Dominance of Sensations (TDS) test, acceptance and purchase intention. The responses of dry matter, ash, protein, carbohydrate, total energy value, pH, color, antioxidant capacity, acid acetic bacteria, mesophilic cocci, viscosity and TDS test showe...
Authors: Zanghì A, D'Amico E, Patti F Abstract IntroductionTherapeutic armamentarium in Multiple Sclerosis (MS) has radically changed in the last few decades due to the development of disease modifying treatments (DMTs) with highly selective mechanisms of action.Areas coveredIn this review, the authors will focus on the current role of immunosuppressive DMTs in the management of the relapsing remitting form of MS (RRMS), moving from the rationale of its use and looking at the possibility to design an idealistic scenario of a personalized approach for each single patient.Expert opinionQuestions remain open about...
PML is a rare infection with JC virus affecting mostly oligodendrocytes and the white matter of the central nervous system. It affects patients with profound cellular immunodeficiency such as uncontrolled HIV or those receiving immunosuppression for neoplastic and autoimmune diseases. Prognosis is poor as there is no effective therapy except for immune recovery which is not feasible in all cases. Herein, we describe using Quadrivalent (CMV,EBV, Adenovirus and BK) VSTs in a recipient of an unrelated donor hematopoietic cell transplant (HCT) with PML.
We report a pediatric case of autoimmune enteropathy (AIE) that was successfully treated with haploidentical SCT and post-transplant cyclophosphamide.
Resetting the immune system through autologous hematopoietic stem cell transplant (autoHSCT) is a highly effective treatment in patients with autoimmune diseases (AID). AutoHSCT achieved long-term remission in patients with relapsed refractory and secondary progressive multiple sclerosis (Muraro 2017), superior to their previous standard of care (Burt 2019). AutoHSCT in scleroderma patients achieved superior outcomes in two randomized studies (Tyndall 2014, Sullivan 2018). These impressive results are achieved by both eradication of autoreactive immune effector cells and re-establishment of a self-tolerant immune system, i...
Autoimmune cytopenias (AIC) are a known complication of hematopoietic stem cell transplant that can lead to increased morbidity and mortality. Higher rates of AIC have been reported in patients transplanted for nonmalignant conditions ranging from 19.5%-56% with the highest rate reported in very young infants ( ≤3 months) with non-malignant diseases who had undergone unrelated cord blood transplants following ablative conditioning with serotherapy.
cGVHD exhibits both autoimmune and fibrotic features across multiple organ systems. KD025 is an orally available Rho-associated coiled-coil kinase 2 (ROCK2) selective inhibitor.
Regulatory T cells (Treg) play a central role in the maintenance of immune tolerance. We previously reported that the altered Treg homeostasis in the prolonged lymphopenia after HSCT is one of the major pathogenesis of impaired Treg recovery leading to the onset of chronic GVHD and low-dose IL-2 can restore normal Treg homeostasis by a PD-1-dependent mechanism, resulting in the improvement of clinical GVHD symptoms. In these years, the tolerogenic effects of IL-2 have been tested for various autoimmune diseases by clinical trials.
This study demonstrates that an engineered DNA nanodrug (TD-P-dODN) enhances the efficacy of nucleic acid drugs and represents a promising strategy for RA treatment.Graphical abstractThe intracellular NF-κB pathway is activated in the inflamed synovium. The degradation of IκB results in the release of the P50/P65 complex that can translocate into the nucleus and initiate the transcription of inflammatory protein. TD-P-dODNs insert across the P50/P65 complex in cytoplasm and inhibit its downstream activities, which ultimately reduces inflammation in vitro and in vivo.
Conclusions. This study brings additional evidences of interest to investigate IgE, D-dimer serum/plasma levels and basophil blood counts in patients with CSU as they could be correlated to disease activity, response to treatment and/or autoimmunity. PMID: 31965967 [PubMed - as supplied by publisher]