Infections Preceding the Development of Dercum disease
Publication date: Available online 19 December 2019Source: IDCasesAuthor(s): Karen Beltran, Rita Wadeea, Karen L. HerbstABSTRACTDercum Disease (DD) is a rare inflammatory disease of painful subcutaneous fat masses with known alterations in lymphatic vessels. DD masses vary from pearl to walnut-size or larger and occur anywhere in body fat. Signs and symptoms of DD are similar to fibromyalgia. While the etiology of DD is unknown, metabolic, autoimmune, or autosomal genetic transmission has been proposed. This series presents 7 cases where DD followed an infection either histoplasmosis, coccidioidomycosis or Lyme disease. Known changes in fat by infectious agents are reviewed. Early diagnosis and treatment of infections may prevent further damage to fat.
Purpose of review Type 2 autoimmune pancreatitis (AIP) is a rare inflammatory disease of the pancreas. Very few data have been published on this particular subtype, which differs from the ‘classical’ IgG4-related type 1 AIP in terms of pathological features, epidemiology and risk of relapse. The aim of the current review is to summarize the available literature, suggesting a diagnostic and therapeutic approach to this disease. Recent findings Based on the International Consensus Diagnostic Criteria, to achieve a ‘definitive’ diagnosis of type 2 AIP, histology is required. If a definitive histol...
LYME disease is a debilitating bacterial infection and with lockdowns easing and more people venturing outside, knowing the potential risks and symptoms is extremely important. If you experience any of these six, lesser-known warning signs you may be at risk.
CONCLUSION: miR-182-5p mimic therapy inhibits the pathogenic Th17 response in EAU mice. miR-182-5p's inhibition of TAF15 negatively regulates Th17 cell development by suppressing STAT3 phosphorylation. As TAF15 shows a positive relationship with Th17 cell markers in uveitis patients, the miR-182-5p/TAF15 axis shows promise as a therapeutic target for uveitis. PMID: 32736708 [PubMed - as supplied by publisher]
Neuromyelitis optica spectrum disorders (NMOSD) are debilitating and life-threatening autoimmune diseases of the central nervous system. Patients usually suffer weakness and blindness (Wingerchuk et al., 2007). NMOSD involve majorly chronic relapsing course result in visual and motor disability. (Wingerchuk et al., 1999). Despite significant advances in our understanding of the clinical and pathological features of NMOSD, what triggers relapse or exacerbation is not fully understood (Mandler, 2006).
This study should encourage labs to explore the use of multiplex ing immunogenicity assays to characterize anti-drug antibody responses quickly, with less repeat testing and reduced sample handling.
ConclusionAlthough the immunological and clinical associations between EIMs and CD cannot be fully elucidated, identifying specific relationships of immune-mediated diseases will help to better understand CD pathogenesis.
ConclusionsOur meta-analysis indicates that the sleep quality of SLE patients is worse than that of the general population; thus, more attention should be paid to the sleep status among this disease.Key Points•The sleep quality of SLE patients is worse than that of the general population.•Region, race, and disease duration are correlated with sleep quality in SLE patients.
AbstractThe pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) are thought to play a role in disease progression and prolongation. These antibodies have been described in patients with severe and chronic AD, suggesting a progression from allergic inflammation to severe autoimmune processes against the skin. This review provides a summary of the current knowledge and gaps on IgE autoreactivity and self-reactive T cells in children and adults with AD based on a systematic se...
Conclusion: We present the characteristics of AIH patients in Central China for the first time. Five microbial biomarkers, including Lachnospiraceae, Veillonella, Bacteroides, Roseburia, and Ruminococcaceae, achieved a high potential distinguishing AIH patients from HCs.
AbstractPurposeTo report causative organisms, visual outcomes, and associated medical conditions in endogenous endophthalmitis (EE).MethodsMicrobiological and medical reports of patients with culture-proven EE referred to Farabi Eye Hospital, Tehran, Iran, from January 2008 to January 2018 were reviewed.ResultsA total of 144 cases (171 eyes) were included in the present study.Candida albicans (30.6%) andStaphylococcus aureus (27.1%) were the most prevalent microbial causes. Diabetes mellitus (43.8%) and IV drug abuse (10.4%) were the leading associated systemic conditions. Age of the patients (P = 0.002) and ...