Microwave Assisted Synthesis And Molecular Docking Studies Of Some 4 - (3h)-Quinazolinone Derivatives As Inhibitors Of Human Gamma-Aminobutyric Acid Receptor, The Gaba (A)R-Beta3 Homopentamer.

CONCLUSION: The Microwave irradiation for synthesis of the title compounds offers reduction in reaction time, operation simplicity, cleaner reaction, easy work up and improved yields. The procedure clearly highlights the advantages of Green Chemistry. The data reported in this article may be a helpful guide for the medicinal chemists who are working in this area. The Protein-Ligand interaction plays a significant role in structural based drug designing. In the Present work we have docked the ligand, 2, 3-disubstituted quinazolinone with the proteins that are used as the target for GABA-A receptor. PMID: 31840612 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research