Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer’s disease, through LPA1/3 and VEGF receptors

ConclusionsWe found that intravenous, but not oral, administration of gintonin facilitates brain delivery of donepezil from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of donepezil for treatment of the AD brain.Graphical abstract
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research