CD22 and CD72 contribute to the development of scleroderma in a murine model
Systemic sclerosis (SSc) is characterized by vascular alterations and extensive fibrosis of the skin, lungs and other internal organs. Although the pathogenesis of SSc has not been elucidated, B cell abnormalities likely play an important role . CD19, a B ‐cell‐specific cell surface molecule that defines signal thresholds critical for humoral immune responses and autoimmunity, is overexpressed on B cells from patients with SSc . In the tight-skin (TSK/+) mouse, a genetic model for human SSc, TSK/+ mice deficient in CD19 expression demonstrated significantly decreased skin fibrosis .
Condition: Systemic Sclerosis Intervention: Biological: AUC of MPA measure Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting
Scleroderma patients treated with filler injections of hyaluronic acid and platelet-rich plasma realized improvements in skin atrophy and quality of life.Arthritis Research &Therapy
We report a 72-year-old man who presented to the dermatology clinic for an 11-year history of edematous legs, occasionally associated with ulcerations. The findings developed within a year of intrapelvic non-Hodgkin lymphoma and progressed gradually over 10 years after lymphoma remission. Physical examination revealed atypical features including compressible cysts and pitting edema extending from the lower legs to the thighs bilaterally. The patient was noncompliant for the recommended compressive devices...
Abstract Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease, kidney disease, drug-induced liver injury, and nonalcoholic steatohepatitis. IL-11 is a member of the IL-6 cytokine family and has several distinct properties that define its unique and nonredundant roles in disease. The IL-11 receptor is highly expressed on stromal, epithelial and polarized cells, where noncanonical IL-11 signaling drives the three pathologies common to all fibro-inflammatory diseases-myofibroblast activation...
eras MT, Bielsa I PMID: 31984476 [PubMed - as supplied by publisher]
Publication date: Available online 25 January 2020Source: Reumatología Clínica (English Edition)Author(s): Lucía Suárez Pérez, Luis Caminal Montero, Luis Trapiella Martínez, Jessica Rugeles Niño
CONCLUSIONS: In our cohort, the prevalence of serodiscordant SSc patients was low. They differed from their counterparts in some clinical manifestations. The management of patients with SSc should be guided by both serology and cutaneous subtype. PMID: 31969223 [PubMed - as supplied by publisher]
CONCLUSIONS: Dilatation score performs best of all semi-quantitative NVC parameters in diagnosing SSc. In addition, our study confirms earlier reports that worse capillaroscopy pattern at baseline correlates with higher likelihood for adverse prognosis. PMID: 31969216 [PubMed - as supplied by publisher]
Neurocognitive impairment and musculoskeletal complications are among the most common complications of long-term allogeneic hematopoietic cell transplant (HCT) survivors, for which recommendations regarding routine screening and therapeutic interventions remain limited. Changes in cognitive functioning have been described in 40% of long-term allogeneic hematopoietic cell transplant survivors, and although the incidence of musculoskeletal complications has not been clearly defined, is very common- ranging from steroid-induced myopathy, myositis related to chronic graft-versus-host disease (GVHD), and fasciitis/scleroderma manifestations.
Resetting the immune system through autologous hematopoietic stem cell transplant (autoHSCT) is a highly effective treatment in patients with autoimmune diseases (AID). AutoHSCT achieved long-term remission in patients with relapsed refractory and secondary progressive multiple sclerosis (Muraro 2017), superior to their previous standard of care (Burt 2019). AutoHSCT in scleroderma patients achieved superior outcomes in two randomized studies (Tyndall 2014, Sullivan 2018). These impressive results are achieved by both eradication of autoreactive immune effector cells and re-establishment of a self-tolerant immune system, i...