Bioinformatics analysis of differentially expressed genes in hepatocellular carcinoma cells exposed to Swertiamarin

Conclusion: Swertiamarin treatment led to significant changes in the expression of a variety of genes that modulate cell survival, cell cycle progression, apoptosis, and invasion. Moreover, most of these genes can be clustered into pathway networks such as PI3K, JUN, STAT3, which are predicted targets of swertiamarin. Further confirmation of these targets will reveal the anti-tumor mechanisms of swertiamarin and facilitate the development of swertiamarin as a novel agent for cancer prevention and treatment.

Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Haoran Tang, Yang Ke, Zongfang Ren, Xuefen Lei, Shufeng Xiao, Tianhao Bao, Zhitian Shi, Renchao Zou, Tiangen Wu, Jian Zhou, Chang-An Geng, Lin Wang, Jijun Chen Tags: Research Paper Source Type: research