Repeated lumbar punctures within 3 days may affect CSF biomarker levels
AbstractLumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers for Alzheimer ’s disease, we investigated CSF biomarker dynamics in relation to rebound sleep after sleep deprivation. Two LPs were performed within 3 days in 13 healthy volunteers. We noticed an unexpected sharp rise in biomarker concentrations in the second sample and therefore repeated the experiment, but w ithout sleep intervention, in four additional individuals. The findings were similar in these subjects, suggesting an inherent methodological problem with repeated LPs. The result corroborates findings in studies with repeated CSF collection via indwelling lumbar catheters, and needs to be addressed in, for instance, pharmacodynamic studies employing these techniques.
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Publication date: 18 January 2020Source: New Scientist, Volume 245, Issue 3265Author(s): Alice Klein
Authors: Herring WJ, Ceesay P, Snyder E, Bliwise D, Budd K, Hutzelmann J, Stevens J, Lines C, Michelson D Abstract INTRODUCTION: We evaluated the clinical profile of the orexin receptor antagonist suvorexant for treating insomnia in patients with mild-to-moderate probable Alzheimer's disease (AD) dementia. METHODS: Randomized, double-blind, 4-week trial of suvorexant 10 mg (could be increased to 20 mg based on clinical response) or placebo in patients who met clinical diagnostic criteria for both probable AD dementia and insomnia. Sleep was assessed by overnight polysomnography in a sleep laboratory. The primar...
Abstract Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). The glia-lymphatic (glymphatic) system facilitates brain fluid clearance and waste removal during sleep via glia-supported perivascular channels. Human studies have implicated impaired glymphatic function in both AD and...
(Alzheimer's Association) Phase 3 drug trial results on improving sleep for persons living with Alzheimer's disease. The US Hispanic/Latino population is predicted to have the largest increase in Alzheimer's and all dementia by mid-century. Artificial intelligence may help with early detection of dementia.
Journal of Clinical Sleep Medicine,Volume 16, Issue 1, Page 157-159, January 2020.
A small group of young, healthy men deprived of just one night of sleep had higher blood levels of tau protein, which is linked to Alzheimer's disease, than when they had a full and uninterrupted night of rest.
Title: Even 1 Night's Bad Sleep Can Raise Levels of a Brain 'Marker' for Alzheimer'sCategory: Health NewsCreated: 1/8/2020 12:00:00 AMLast Editorial Review: 1/9/2020 12:00:00 AM
Levels of Alzheimer's-causing proteins in the blood may increase after the loss of only one night's sleep, a study says.
Swedish researchers behind the study are warning students and employees who stay up all night to finish a work or university project. They were shocked by the findings.