Compound Clear Cell Sarcoma of the Skin—A Potential Diagnostic Pitfall: Report of a Series of 4 New Cases and a Review of the Literature

In conclusion, an epidermal component in primary cutaneous clear cell sarcomas, or cutaneous metastasis of the tumor, is exceptional and represents a potential diagnostic pitfall. Careful attention to the salient morphologic features in the dermal component of the tumor, as well as confirmation of EWSR1 gene rearrangement by fluorescence in situ hybridization or reverse transcriptase polymerase chain reaction, is necessary for correct recognition of the tumor and to avoid erroneous diagnosis of a benign or malignant melanocytic proliferation.
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research