B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B

Conditions:   HIV Infection;   Hepatitis B Interventions:   Biological: HEPLISAV-B;   Biological: ENGERIX-B Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Dynavax Technologies Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Cases of a novel pneumonia-like illness that originated in Wuhan, China in December have now been confirmed in South Korea, Thailand, Japan, Taiwan, Macau—and, as of Jan. 21, the U.S. The virus’ geographic reach, as well as its newly discovered ability to spread via person-to-person contact, has health officials worried about the prospect of globals spread. As health officials scramble to learn more about the virus and is origins, researchers are simultaneously turning to the question of how to develop a vaccine or therapy that could help contain transmission worldwide—a feat that experts say is technical...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Infectious Disease Source Type: news
CONCLUSION We identified a population of HCV-specific CD4+ T cells with a follicular T helper cell signature that is maintained after therapy-induced elimination of persistent infection and may constitute an important target population for vaccination efforts to prevent reinfection and immunotherapeutic approaches for persistent viral infections.FUNDING Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), the National Institute of Allergy and Infectious Diseases (NIAID), the European Union, the Berta-Ottenstein-Programme for Advanced Clinician Scientists, and the ANRS.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Australian infants who received the whole pertussis (wP) vaccine were less likely to be diagnosed with food allergies than those who received the acellular pertussis (aP) vaccine in a nested case control study.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pediatrics News Source Type: news
In this study combination of immuno-informatics and molecular docking approach was used to constitute a MEBP vaccine. The ZIKV proteome was used for prediction of B-cell, T-cell (HTL &CTL) and IFN-γ epitopes. After prediction, highly antigenic and overlapping epitopes have been shortlisted which includes 14 CTL and 11 HTL epitopes that have been linked to the final peptide through AAY and GPGPG linkers respectively. An adjuvant at the N-end of the vaccine was added to improve the immunogenicity of the vaccine through the EAAAK linker. The final construct constitutes 435 amino acids after the addition of linkers a...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
This study of 73 LNs demonstrates that human LN FNAs are a safe and feasible technique for immunological research, and suggests benchmarks for human GC biology under noninflammatory conditions. The findings indicate that assessment of the GC response via LN FNAs will have application to the study of human vaccination, allergy, and autoimmune disease. PMID: 31958451 [PubMed - as supplied by publisher]
Source: Journal of Immunological Methods - Category: Allergy & Immunology Authors: Tags: J Immunol Methods Source Type: research
(CNN) — This year’s flu vaccine is “not a very good match” for a common strain of the flu that’s especially tough on children, according to the nation’s top infectious disease doctor. “It’s not a very good match for B/Victoria,” said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, referring to the strain. “It’s not an awful match, but it’s not a very good match.” Children are particularly susceptible to influenza B/Victoria. Fauci said even though the match for B/Victoria isn’t great, a flu shot can...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Flu Vaccine Source Type: news
The current flu season is on track be one of the worst in years, Director of the National Institute of Allergies and Infectious Diseases Dr. Anthony Fauci told CNN. CNN reports that Fauci says the 2019-2020 flu season is on track to be as severe as the 2018-2017 season, which was the deadliest in at least a decade. New data from the CDC released on Friday estimates that so far this season, at least 6.4 million people have caught the flu, 55,000 people have been hospitalized and 2,900 people have died — 800 more people then were estimated the week before. According to the latest CDC in-season flu burden estimates, ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Health Care onetime Source Type: news
Giving the vaccine intravenously to monkeys provided 90% protection against tuberculosis. More testing is needed before humans can be inoculated that way.
Source: NYT - Category: American Health Authors: Tags: Tuberculosis Vaccination and Immunization Monkeys and Apes Lungs Third World and Developing Countries National Institute of Allergy and Infectious Diseases University of Pittsburgh Nature (Journal) Seder, Robert A Africa your-feed-heal Source Type: news
(NIH/National Institute of Allergy and Infectious Diseases) Tuberculosis (TB), an ancient disease, is the leading infectious cause of death globally, yet the world's only licensed TB vaccine, Bacille Calmette-Guerin (BCG), was developed a century ago. Given to infants via a needle placed just under the skin, BCG protects babies from a form of the disease called disseminated TB but is far less effective at preventing pulmonary TB, the major cause of illness and deaths, in teens or adults.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Even a single dose of human papillomavirus (HPV) vaccine is associated with a reduced prevalence of HPV infection among U.S. women, according to findings from the National Health and Nutritional Examination Survey (NHANES).Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention News Source Type: news
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