MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling

Conclusions/interpretationsThis study provides compelling evidence about the critical role of miR-132 for the regeneration of mouse islet beta cells through the downregulation of its target Pten. Hence, the miR-132/Pten/Akt/Foxo3 signaling pathway may represent a suitable target to enhance beta cell mass.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research