Gene Editing Expands the Donor Pool for CCR5-Negative Stem Cell Transplants.
Gene Editing Expands the Donor Pool for CCR5-Negative Stem Cell Transplants.
Cell Stem Cell. 2019 Dec 05;25(6):735-736
Authors: Cannon PM
Abstract
Cell therapy efforts for treating HIV+ patients are challenged by limited availability of donors with naturally occurring CCR5 mutations conferring resistance. Xu et al. (2019) report a CRISPR-based method for disrupting CCR5 in hematopoietic stem cells prior to transplant, providing a proof of concept for expanding the pool of potential donors.
PMID: 31809736 [PubMed - in process]
Source: Cell Stem Cell - Category: Stem Cells Authors: Cannon PM Tags: Cell Stem Cell Source Type: research