New diagnostic tools for delineating iron status.

New diagnostic tools for delineating iron status. Hematology Am Soc Hematol Educ Program. 2019 Dec 06;2019(1):327-336 Authors: Ginzburg YZ Abstract Recent advances in our understanding of iron metabolism regulation and crosstalk with erythropoiesis have provided insight into the pathophysiology of multiple disease conditions. For instance, the peptide hormone hepcidin is central to the regulation of iron metabolism. Its effect on cellular iron concentration involves binding ferroportin, the main iron export protein, resulting in its internalization and degradation and leading to iron sequestration within ferroportin-expressing cells. Furthermore, hepcidin regulation by erythropoiesis is attributed in large part to a bone marrow-derived hormone erythroferrone. Erythroferrone-induced hepcidin suppression in diseases of expanded hematopoiesis results in iron overload. Conversely, diseases, such as iron refractory iron deficiency anemia and anemia of chronic inflammation, are characterized by aberrantly increased hepcidin, resulting in iron sequestration and decreased circulating iron and eventually leading to iron-restricted erythropoiesis. Lastly, because iron functions in concert with erythropoietin to promote erythroid precursor survival, proliferation, and differentiation, iron deficiency anemia is a consequence not only of decreased hemoglobin synthesis in each cell but also, a decrease in erythropoietin responsiveness in the bone marrow. How to transla...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

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ConclusionThe surgical option remains the standard of treatment and can be performed safely in Gastro-Gastric Fistula Type II. Orogastric tube accidental complications should be identified preferably perioperatively and measures of prevention should be implied to avoid such events.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionVE is a new useful tool for the preoperative collection of data on small polypoid lesions in the small bowel.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conclusion: Although AIG is rare in children, pediatric gastroenterologists and pathologists should have a heightened suspicion for this entity in those patients with a history of autoimmune disorders and/or pernicious anemia.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Short Communications: Gastroenterology Source Type: research
Publication date: Available online 22 January 2020Source: Process BiochemistryAuthor(s): Bhawna Batra, Vinay Narwal, Vijay Kalra, Minakshi Sharma, JS RanaAbstractFolic acid (FA) also known as (N-[p-{[(2-amino-4-hydroxy-6-pteridinyl) methyl] amino} benzoyl]-l-glutamic acid), is a water soluble vitamin found in plants and animals. The deficiency of FA leads to an increased risk of various diseases like neural tube defects in newborn, cardiovascular disease, cancer, Alzheimer’s disease and megaloblastic anemia. The normal levels of FA in human blood serum should fall in the range between 2 and 15 ng/mL. Present r...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
In conclusion, TRNT1 mutations may lead to multiple immune abnormality especially humoral and cytotoxicity defects, which indicate that SIFD is not only suffered ‘Predominantly antibody deficiencies’ in IUIS classification system, and further studies are needed to understand the pathogenesis of immunodeficiency in these patients.
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 23 January 2020Source: American Journal of Preventive MedicineAuthor(s): Anjali V. Ganpule-Rao, Devesh Roy, Bhushana A. Karandikar, Chittaranjan S. Yajnik, Elaine C. RushIntroductionThe relationships among food access, foods consumed, and nutritional status and health in developing countries are not well understood. Between 2013 and 2018, differences in the rural food environment and access to food, nutritional status, and body size in the rural villages where the Pune Maternal Nutrition birth cohort was recruited were measured and analyzed.MethodsFood access measures included the number ...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
CONCLUSIONS: acromegaly may be associated with more polyps in SB. PMID: 31960686 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Authors: Ruiz Rebollo ML, González Obeso E, Burgueño Gómez B, Santos Fernández J Abstract A 75-year-old male was referred due to dysphagia and iron-deficiency anemia. An upper endoscopy was performed which revealed a friable mass at 30 to 37 cm from the incisors, consistent with esophageal malignancy. However, the pathology only demonstrated granulation inflammatory tissue. An endoscopic ultrasound exam showed a 2-3 cm esophageal wall thickening with a 1.5 cm lymph node, which was staged as a T2-3 N1 esophageal tumor. A CT-scan also identified a 7.5 cm esophageal malignancy surrounded by...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
(University of Washington Health Sciences/UW Medicine) 3D microvessels have been created to observe how red blood cells transit ultra-small blood vessels. They squeeze single-file through microvessels to bring oxygen and nutrients. Red cells burdened with malaria stall, blocking the blood vessel. The platform is expected to have other uses in studies of how microvascular damage occurs in diabetes and sickle cell anemia. They might be further developed to supply blood circulation to organ repair patches or to 3D printed transplants.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Aplastic anemia (AA) is a rare disorder characterized by pancytopenia and bone marrow failure. The majority of severe aplastic anemia (SAA) cases are acquired immune-mediated, or sometimes triggered by known environmental or toxic exposures (Miano and Dufour 2015). Inherited forms of bone marrow failure do exist, such as Fanconi anemia (FA) which is the most common. FA is due to pathogenic germline variants in one of 22 FA/BRCA DNA repair pathway genes (so far 20 autosomal recessive, one X-linked, one autosomal dominant), resulting in defects in DNA damage repair, specifically the inability to repair inter-strand cross lin...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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