Barthel Index and modified Rankin Scale: psychometric properties during medication phases in idiopathic Parkinson disease

Conclusion: The BI and mRS showed acceptable validity and reliability to measure the degree of disability in patients with PD in daily activities in both ON and OFF medication phases.
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research

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This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: K-PDSS-2 showed good clinimetric attributes in accordance with previous studies that employed the original version of the PDSS-2, therefore confirming the cross-cultural usefulness of the scale. This study has further documented the first application of an LCA approach for identifying subtypes of sleep disturbance in patients with PD. PMID: 31942760 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
DiscussionThe results of this trial will have an immediate impact on the current care of people with PD. We hypothesize that by offering more patients access to PDNS care, quality of life will increase. We also expect healthcare costs to remain equal because increases in direct medical costs (funding additional nurses) will be offset by a reduced number of consultations with the general practitioner and neurologist. If these outcomes are reached, wide implementation of PDNS care will be warranted.Trial registrationClinicalTrials.gov,NCT03830190. Registered February 5, 2019 (retrospectively registered).
Source: Trials - Category: Research Source Type: clinical trials
Conclusion: Cognitive disability was associated with greater disability in moderate to advanced PwP than non-ambulatory status. The results of this study may indicate that cognition preservation is essential to ameliorate functional impairment and disability in moderate to advanced PwP.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disorder with chronic inflammation in central nervous system, manifested by both physical and cognitive disability. Neuroinflammation and neurodegeneration are the phenomena that appear in the central nervous system associated with various neurodegenerative disorders including MS, Alzheimer's diseases, amyotrophic lateral sclerosis and Parkinson's disease. Prostaglandins are one of the major mediators of inflammation, that exhibit the important function in enhancing neuroinflammatory and neuro degenerative processes. These mediators would help to unde...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
This study investigates the relationship between daytime sleepiness and presynaptic monoamine transporter densities of the basal ganglia in patients with early PD. Sixty-four patients with early PD who were evaluated with positron emissio n tomography (PET) using18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane were enrolled. EDS was evaluated with the Epworth Sleepiness Scale (ESS); nocturnal disabilities and nighttime sleep problems were assessed with Parkinson ’s Disease Sleep Scale 2nd version. PET images were normalized, and the standardized uptake value ratios (SUVRs) for caudate, putam...
Source: Neurological Sciences - Category: Neurology Source Type: research
ConclusionsOrthostatic syndromes were common in the recently diagnosed drug-na ïve patients with PD enrolled in the study, but only the prevalence of OI was higher in PD patients than in the non-parkinsonian controls. Unlike motor or functional disability indicators, markers of dopaminergic striatal deficit and gastrointestinal dysfunction were associated with OH and OI.
Source: Clinical Autonomic Research - Category: Research Source Type: research
miRNA‑384‑5p regulates the progression of Parkinson's disease by targeting SIRT1 in mice and SH‑SY5Y cell. Int J Mol Med. 2019 Dec 12;: Authors: Tao H, Liu Y, Hou Y Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder. miR‑384‑5p expression has been shown to be increased in an in vitro model of PD; however, it remains unknown whether there are other molecules that can be regulated by miR‑384‑5p in in vivo and in vitro models of PD; thus, the present study aimed to elucidate this matter. Rotenone was applied for the establishment of in...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
In conclusion, Parkinson’s Disease Multimodal Complex Treatment improves motor symptoms, depression and quality of life. A more detailed selection of patients who will benefit best from this interve ntion should be examined in future studies.
Source: Journal of Neurology - Category: Neurology Source Type: research
Authors: Franciotta M, Maestri R, Ortelli P, Ferrazzoli D, Mastalli F, Frazzitta G Abstract Background: Hand functionality and finger dexterity are impaired in patients with Parkinson's disease (PD). These disturbances lead to a dependency in activities of daily living (ADL) and poor quality of life (QoL). Objective: We aimed to evaluate whether a specific occupational therapy (OT) program is effective in improving finger and hand dexterity and its impact on ADL in PD patients. Methods: We retrospectively studied PD patients, hospitalized for a 4-week multidisciplinary intensive rehabilitation treatment (MI...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
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