Risk of Hypersensitivity Reactions to Iopromide After Intra-Arterial Versus Intravenous Administration: A Nested Case-Control Analysis of 133,331 Patients

Objective The aim of this study was to compare the risk of hypersensitivity reactions to iopromide after intra-arterial (IA) administration and intravenous (IV) administration. Materials and Methods Four observational studies were pooled. Almost half of the study population (48.1%) was from Europe, and one quarter each from China (27.6%) and other Asia countries (24.1%). All patients received iopromide either intra-arterially or intravenously for angiographic procedures (mostly cardio-angiography) or contrast-enhanced computed tomography. A nested case-control analysis, including a multivariable logistic regression model, was performed. Cases were defined by patients with a typical and unequivocal hypersensitivity (assumed non–IgE-mediated) reaction; controls were patients without any recorded reaction. The primary target variable is the odds ratio of having a hypersensitivity reaction after IA versus IV administration. Results A total of 133,331 patients met the inclusion criteria, 105,460 and 27,871 patients received iopromide IV or IA, respectively. Hypersensitivity reactions were recorded for 822 patients, and 132,509 patients served as controls. Major risk factors for hypersensitivity reactions were method of injection (IV vs IA), age (18 to
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research

Related Links:

ConclusionsLobar and tumor volume measurement with CBCT is a reliable alternative to measurement with preprocedural MRI. Utilization of CBCT 3D segmentation software during planning angiography may be useful to provide up-to-date volume measurements and dose calculations prior to radioembolization.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Source Type: research
More News: Angiography | Cardiology | China Health | CT Scan | Heart | Radiology | Study