Subsequent development of histiocytic sarcoma and follicular lymphoma: cytogenetics and next-generation sequencing analyses provide evidence for transdifferentiation of early common lymphoid precursor —a case report and review of literature

This report strengthens the hypothesis of a common lymphoid progenitor which accumulates genetic alterations leading to two different hematologic malignant diseases with significa ntly distinct prognoses.
Source: Virchows Archiv - Category: Pathology Source Type: research

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Publication date: Available online 8 January 2020Source: Cancer EpidemiologyAuthor(s): W.T. Johnston, Friederike Erdmann, Robert Newton, Eva Steliarova-Foucher, Joachim Schüz, Eve RomanAbstractBackgroundMost of the world’s population is not covered by cancer surveillance systems or vital registration, and worldwide/UN-regional cancer incidence is estimated using a variety of methods. Quantifying the cancer burden in children (
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Conclusion: ADC values play a limited role in distinguishing between malignant and benign lesions in the head and neck region. It may be only suggested that lesions with mean ADC values above 1.75 × 10−3 mm2/s are probably benign. Further large studies are needed for the analysis of the role of diffusion-weighted imaging (DWI)/ADC in the discrimination of benign and malignant lesions in the head and neck region.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Albert Rizvanov Chimeric antigen receptor (CAR) immunotherapy is one of the most promising modern approaches for the treatment of cancer. To date only two CAR T-cell products, Kymriah® and Yescarta®, have been approved by the Food and Drug Administration (FDA) for the treatment of lymphoblastic leukemia and B-cell lymphoma. Administration of CAR T-cells to control solid tumors has long been envisaged as one of the most difficult therapeutic tasks. The first two clinical trials conducted in sarcoma and neuroblastoma patients showed clinical benefits of CAR T-cells, yet multiple obstacles still hold us ba...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
We report a rare case of cutaneous PEL with an unusual intravascular presentation, combined with Kaposi sarcoma involving the skin, lung, and gastrointestinal tract. The molecular genetic analysis of the sarcoma and lymphoma components, using next-generation sequencing was performed. The patient was a 67-year-old man who presented with multiple cutaneous tumors and mass in the left lung. He died 17 hours after the admission to the hospital. At autopsy, in addition to the cutaneous lesions, tumors in the left lung and gastrointestinal mucosa were detected, and no effusions in the body cavities were seen. The biopsy from the...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
AbstractRadiation therapy represents an important approach in the therapeutic management of children and adolescents with malignant tumors and its application with modern techniques – including Proton Beam Therapy (PBT) – is of great interest. In particular, potential radiation-induced injuries and secondary malignancies – also associated to the prolonged life expectancy of patients – are still questions of concern that increase the debate on the usefulness of PBT in pe diatric treatments. This paper presents a literary review of current applications of PBT in non-Central Nervous System pediatric tu...
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
AbstractBackgroundIn clinical routine, SUVmax and SUVpeak are most often used to determine the glucose metabolism in tumours by18F-FDG PET/CT. Both metrics can be further normalised to SUVs in reference regions resulting in a SUV ratio (SUVratio). The aim of the study was to directly compare several widely used SUVs/SUVratios with regard to differentiation between common tumours in paediatric patients; a special focus was put on characteristics of reference region SUVs.MethodsThe final study population consisted of 61 children and adolescents with diagnoses of non-Hodgkin lymphoma (NHL,n = 25), Hodgkin lymphoma (HL,n = 14)...
Source: EJNMMI Research - Category: Radiology Source Type: research
Viruses, Vol. 12, Pages 12: The Zebrafish Xenograft Platform—A Novel Tool for Modeling KSHV-Associated Diseases Viruses doi: 10.3390/v12010012 Authors: Eric S. Pringle Jaime Wertman Nicole Melong Andrew J. Coombs Andrew L. Young David O’Leary Chansey Veinotte Carolyn-Ann Robinson Michael N. Ha Graham Dellaire Todd E. Druley Craig McCormick Jason N. Berman Kaposi’s sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunos...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
An exploratory study was conducted to examine the quality of life and pain experienced by patients with pediatric cancer at home after discharge. Physical, cognitive, social, and emotional aspects of quality of life were measured and how these may be affected by age, sex, diagnosis, and pain status. The authors also characterized intensity, location, and quality of pain experienced. A sample of 33 patients participating in a larger study was selected on the basis of having pain on the day of discharge and having completed the Pediatric Quality of Life Inventory Generic, Cancer Module, Multidimensional Fatigue Scale, and th...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Original Articles Source Type: research
g Qin Viral lymphomagenesis induced by infection with oncogenic viruses, such as Kaposi’s sarcoma associated herpesvirus (KSHV), Epstein–Barr virus (EBV) and human T-cell leukemia virus (HTLV-1), represents a group of aggressive malignancies with a diverse range of pathological features. Combined chemotherapy remains the standard of care for these virus-associated lymphomas; however, frequent chemoresistance is a barrier to achieving successful long-term disease-free survival. There is increasing evidence that indicates virus-associated lymphomas display more resistance to cytotoxic chemotherapeutic...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
ConclusionsThe application of this panel of markers can help the diagnosis of oral MLs, in particular the distinction between fibroblastic, myofibroblastic, and muscle cells proliferation.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
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