T cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy

Conclusion: PD-1HI T cells persist in blood despite prolonged suppression on ART, correlate with HIV DNA levels, and are associated with lower HIV-specific T-cell responses but not CMV-specific or EBV-specific responses, suggesting that these cells are HIV-specific. The findings support evaluating PD-1 blockade strategies for their effect on HIV persistence and HIV-specific immunity.
Source: AIDS - Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research