Interleukin-2 Is a Potential Biomarker for Celiac Disease Interleukin-2 Is a Potential Biomarker for Celiac Disease

Should clinicians consider ordering pre and post interleukin-2 levels with an oral gluten challenge to help diagnose celiac disease?Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Source: Journal of Pediatric Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of gluten and characterized by reversible small-bowel mucosal atrophy in genetically predisposed subjects. Although the prevalence of CD has increased, many aspects of this pathology are still unrecognized. Candida albicans, a commensal of the human gastrointestinal tract, has been linked to CD for a long time based, among others, upon the observation of similarity between the fungal wall component, hyphal wall protein 1, and CD-related gliadin T-cell epitopes. We have recently demonstrated that Candida may switch from commensal to pathogen conti...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 2 December 2019Source: LWTAuthor(s): A.O. Olojede, A.I. Sanni, K. BanwoAbstractSorghum, being gluten-free, is often recommended as a safe food for celiac patients as gluten is associated with celiac disease. However, gluten absence in cereals causes technological inadequacies. Sourdough fermentation using functional starter cultures could produce desirable properties in gluten-free cereals. Sorghum flour was subjected to sourdough fermentation using functional lactic acid bacteria and yeast as starter cultures and their effects on the rheology, texture and nutritional properties of the so...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Multiple studies have examined the association between psoriasis and celiac disease (CD). However, these studies have shown conflicting results.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Publication date: Available online 2 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Jamilya Khizroeva, Cecilia Nalli, Victoria Bitsadze, Andrea Lojacono, Sonia Zatti, Laura Andreoli, Angela Tincani, Yehuda Shoenfeld, Alexander MakatsariyaAbstractInfertility consists by definition in ” failure to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse” while the term subfertility means a delay to achieve pregnancy. Several factors can contribute to infertility or subfertility in patients with systemic autoimmune diseases. The asso...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Celiac disease (CD) affects approximately 1% of the general population, although most cases remain unrecognized. Because CD is a multisystem disorder with protean clinical manifestations, a high index of suspicion is needed to make an appropriate diagnosis. A diagnosis of CD is made in a patient who is genetically predisposed based on the presence of compatible clinical features, positive highly specific celiac serologic findings, duodenal biopsies that document enteropathy, and improvement with a gluten-free diet.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Thematic review series on gastroenterological diseases Source Type: research
CONCLUSION: NRS was more sensitive than other indicators in the diagnosis of malnutrition. Patients at risk were older and had lower HEC values, calf circumference, BMI and lymphocyte count. Low lymphocyte count was considered a factor associated with nutritional risk by the NRS.RESUMO CONTEXTO: A desnutri ção está associada a fatores clínicos, incluindo maior tempo de internação, aumento da morbimortalidade e custos hospitalares. OBJETIVO: Investigar a prevalência de desnutrição por diferentes indicadores nutricionais e identificar fatores que contribuem para a...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
R áki M, Dahal-Koirala S, Yu H, et al. Similar responses of intestinal T-cells from untreated children and adults with celiac disease to deamidated gluten epitopes. Gastroenterology 2017;153:787–798.
Source: Gastroenterology - Category: Gastroenterology Tags: Correction Source Type: research
Authors: Trovato CM, Montuori M, Valitutti F, Leter B, Cucchiara S, Oliva S Abstract Potential celiac disease (PCD) is defined by the presence of positive serum antibodies, HLA-DQ2/DQ8 haplotypes, and a normal small intestinal mucosa (Marsh grade 0-1). This condition occurs in one-fifth of celiac disease (CD) patients and usually represents a clinical challenge. We reviewed genetic, histologic, and clinical features of this specific condition by performing a systematic search on MEDLINE, Embase, and Scholar database. Accordingly, we identified different genetic features in patients with PCD compared to the classica...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
We report on the case of full clinical picture of severe hypothyroidism in one of the twins. Thyroid function deteriorated in one of the sisters, resulting in mental, motor and growth slowdown, remaining undiagnosed for about 2 years, while the other sister developed normally. In the reported case, severe hypothy-roidism and growth deficiency were accompanied by celiac disease. Initiation of L-thyroxine therapy resulted in an immediate response that increased the growth velocity by more than 2.2 times. This confirms the dominant role of thyroid hormones over celiac disease in the growth process, as the catch up effect star...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - Category: Endocrinology Authors: Tags: Pediatr Endocrinol Diabetes Metab Source Type: research
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