The Use of Gene Expression Profiling in Lung Transplantation

AbstractPurpose of ReviewGene expression profiling is increasingly being used to better elucidate the physiology that occurs after lung transplantation. Through better understanding of the mechanisms of rejection, researchers demonstrate potential targets for future therapeutics as well as less invasive means of detecting rejection. We reviewed recently published literature that focused on the use of gene expression in lung transplant recipients in order to determine if there were trends in the genetic pathways involved in rejection.Recent FindingsIn our review, we found significant roles for both the innate and adaptive immunities that spanned across several studies. Gene expression related to T cell maturation and signaling was also significant represented.SummaryGene expression research will allow scientists to improve diagnostics and therapeutics for lung transplant recipients which hopefully, in turn, will improve long-term rejection-free survival. As the cost and difficulty of performing this type of analysis decrease, precision treatments and diagnostics will expand significantly.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research