Role of interferon-gamma as a marker of asthma severity and control

Conclusions: Our observations suggest detrimental effect of IFN in asthma pathogenesis.The study was supported by RFBR (#18-54-53019).
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research

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Conclusion: A more pronounced quantitative content and a more diverse microbial landscape leads to a more severe course of the disease asthma combined with COPD, especially of the bronchitis type.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Aim: to determine the value of the parameters of microcirculation (MC) in children with bronchial asthma (BA) and acute obstructive bronchitis (AOB).Methods: 78 children aged from 2 to 17 years with the mild BA in exacerbation or incomplete remission (group (Gr) 1) and 20 children of the same age with AOB (Gr2) were examined. Catamnesis lasted from 6 to 18 months. The control group (C) included 60 healthy children. All patients underwent examination and computerized nailfold capillaroscopy (NCS).Results: It was found that patients of Gr1 in contrast to Gr2 and C, were characterized by deformation of all parts of the capill...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
CONCLUSIONS: NAEB, CVA, and UACS are common causes of chronic cough in patients with AR. FeNO can first be used to discriminate patients with CVA/NAEB, then FEF25-75 (or combined with FeNO) can further discriminate patients with CVA from those with CVA/NAEB. PMID: 31552718 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Publication date: July–August 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 6Author(s): Sarah Diver, Richard J. Russell, Christopher E. BrightlingEosinophilic airway inflammation is observed in 30% to 50% of chronic cough sufferers. It is a common feature of asthma and upper airway cough syndrome, and it is required in the diagnosis of nonasthmatic eosinophilic bronchitis. Our understanding of the mechanisms underlying allergic and nonallergic eosinophilic inflammation have evolved tremendously in the last 2 decades, but the cause of this inflammation in any individual is of...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Agriculture exposures are associated with reducing the risk of allergy and asthma in early life; yet, repeated exposures later in life are associated with chronic bronchitis and obstructive pulmonary diseases....
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
Publication date: Available online 2 March 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Yunus Çolak, Shoaib Afzal, Peter Lange, Lars C. Laursen, Børge G. Nordestgaard, Morten DahlAbstractBackgroundCough is a well-recognized symptom in asthma, but the role and impact of chronic cough in individuals with asthma has not been described in the general population.ObjectiveWe hypothesized that among individuals with asthma, those with chronic cough versus those without have a more severe disease phenotype.MethodsWe identified individuals with asthma and chronic cough among 14,740...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The objectives of this study are to: 1) compare Ig levels in serum and sputum in such patients compared to normal healthy controls and 2) to compare the effects of subcutaneous (SC) and intravenous (IV) Ig replacement on sputum and serum Ig levels and clinical outcomes.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Increased levels of sputum autoantibodies (aAbs) were reported in the airways of severe asthmatics with recurrent infective bronchitis. We hypothesized that autoantibody-mediated macrophage (M φ) dysfunction could contribute to impaired host defence.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
We examined the association of PFASs measured in pregnancy with childhood asthma, allergies and common infectious diseases in a prospective pregnancy cohort followed to age 7 years. MATERIAL AND METHODS: Six PFASs (out of 19 measured) with at least 80% of measurements above the limit of quantification (LOQ) in maternal plasma during pregnancy in two subcohorts of the Norwegian Mother and Child Cohort Study (MoBa) were analyzed in relation to health outcomes: perfluorooctane sulfonic acid (PFOS), acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDA), and ...
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
Pulmonary function tests check the lungs for issues including asthma, allergies, and bronchitis. Learn more about what pulmonary functions tests are for, and how they work, here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory Source Type: news
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