Allyl isothiocyanate up-regulates MRP1 expression through Notch1 signaling in human bronchial epithelial cells.

In conclusion, Notch1 signaling positively regulated MRP1 in 16HBE cells, and AITC induced MRP1 expression and function may be attributed to Notch1 signaling. These findings show that Notch1 and MRP1 might have a potential protective effect in the COPD process and become a new therapeutic target for COPD or other lung diseases. It also provides theoretical basis for the therapeutic effects of AITC. PMID: 31747319 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research