Multimodal image-guided surgery of HER2-positive breast cancer using [ 111 In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model

ConclusionsDual-labeled trastuzumab showed specific accumulation in orthotopic HER2-positive BT474 breast tumors with micro-SPECT/CT and fluorescence imaging and enabled image-guided tumor resection. In the clinical setting, [111In]In-DTPA-trastuzumab-IRDye800CW could be valuable for preoperative detection of (metastatic) tumors by SPECT/CT imaging, and intraoperative localization by using a gamma probe and fluorescence image-guided surgery to improve radical resection of tumor tissue in patients with HER2-positive tumors.
Source: EJNMMI Research - Category: Radiology Source Type: research