N-WASP Guides Cancer Cells toward LPA.

N-WASP Guides Cancer Cells toward LPA.
Dev Cell. 2019 Nov 18;51(4):415-417
Authors: Rottner K, Schaks M
Abstract
The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent chemotaxis and metastasis of pancreatic cancer cells.
PMID: 31743660 [PubMed - in process]

Source: Developmental Cell - November 17, 2019 Category: Cytology Authors: Rottner K, Schaks M Tags: Dev Cell Source Type: research