Broader Geographic Sampling Increases Extent of Intermediate Host Specificity for a Trematode Parasite (Notocotylidae: Quinqueserialis quinqueserialis).

Broader Geographic Sampling Increases Extent of Intermediate Host Specificity for a Trematode Parasite (Notocotylidae: Quinqueserialis quinqueserialis). J Parasitol. 2019 Dec;105(6):874-877 Authors: Gagnon DK, Detwiler JT Abstract Knowledge of helminth life cycles is essential to understanding their host specificity, geographic distribution, and transmission. Many helminth life cycle descriptions are based on field collections in a limited part of the parasite's range. However, it is important to determine whether helminth life cycles and host specificity remain consistent across their geographic range so that we may better understand their life history and transmission ecology. Here, we investigated whether the life cycle of a widespread trematode, Quinqueserialis quinqueserialis (Notocotylidae) varies across its geographic range. Four species of planorbid snails; Gyraulus circumstriatus, Gyraulus crista, Planorbula sp., and Promenetus exacuous, were collected at 5 locations in Canada (3 in Manitoba, 2 in Northwest Territories). Snails and parasite larvae were morphologically and genetically identified to species. The total prevalence of Q. quinqueserialis infections in snail hosts among the 5 locations was 2.3% (n = 1,017). Three species of snails were infected with Q. quinqueserialis rediae: G. circumstriatus, G. crista, and P. exacuous. Two of the 3 species of snails were infected in central (Manitoba) and northern locations (Northwest Territories) w...
Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research

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mé IS, Castro N, Jung-Cook H Abstract Based on our previous research on cysticidal drugs, we report the synthesis and evaluation of three new benzimidazole derivatives. In these compounds, the amido group was used as a bioisosteric replacement of the ester group. The molecular docking on β-tubulin revealed that the derivatives interacted through hydrogen bonding with N165, E198 and V236. All compounds showed in vitro activity against Taenia crassiceps cysts. Among them, benzimidazole 3 was found to be the most potent of the series (EC50 0.86 µM). This compound also exhibited the highest pr...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
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Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
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Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
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