Role of the small proteoglycan bikunin in human reproduction.

CONCLUSIONS: Because of its pleiotropic roles in several reproductive events and its association with some life-threatening pathological conditions of pregnancy, bikunin may represent a non-invasive marker for improving follow-up and early diagnosis. Studies showing its usefulness as a drug for reducing the risk of preterm delivery and improving neonatal outcomes have yielded interesting results that deserve to be investigated through further research. PMID: 31728877 [PubMed - as supplied by publisher]
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Related Links:

Publication date: December 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 8Author(s): Alexandra Pouliot, Riham Elmahboubi, Catherine AdamAbstractObjectivesAt 1 Canadian university hospital, pregnant women were routinely screened for gestational diabetes mellitus (GDM) with a 75-g oral glucose tolerance test (OGTT). Diagnostic plasma glucose thresholds were as follows: fasting: ≥5.3 mmol/L, 1 h: ≥10.6 mmol/L and 2 h: ≥9.0 mmol/L. In 2015, diagnostic thresholds were reduced to those recommended by the International Association of Diabetes in Pregnancy Study Group (IADPSG) as follows: fasting: ≥5.1 mmo...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
This study used an Agilent 7900 inductively coupled plasma mass spectrometer (ICP-MS) to simultaneously measure 68 elements, in 166 placental cord blood samples collected from women with various pregnancy complications (control, hypertensive, PE, GDM, FGR, pre-term, and post-term birth).ResultsThere were single element differences across gestational outcomes for elements Mg, P, Cr, Ni, Sr, Mo, I, Au, Pb, and U. Hypertensive and post-term pregnancies were significantly higher in Ni concentrations when compared to controls (control = 2.74 µg/L, hypertensive = 6.72 µg/L, p...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Objectives: Either maternal gestational diabetes mellitus (GDM) or hypertensive disorder of pregnancy (HDP) is associated with an increased risk of obesity in the offspring. However, their joint associations with obesity in offspring remain unclear. We investigated the joint associations of maternal GDM and HDP with childhood overweight in offspring.Methods: We performed a large study in 1967 mother-child pairs. Maternal GDM was diagnosed according to the 1999 World Health Organization (WHO) criteria. HDP was defined as self-reported doctor-diagnosed hypertension or treatment of hypertension (including gestational hyperten...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
CONCLUSIONS: Two new studies (406 women) have been incorporated to one of the comparisons for this update. Although the evidence suggests that CGM in comparison to intermittent glucose monitoring may reduce hypertensive disorders of pregnancy, this did not translate into a clear reduction for pre-eclampsia, and so this result should be viewed with caution. No differences were observed for other primary outcomes for this comparison. The evidence base for the effectiveness of other monitoring techniques analysed in the other five comparisons is weak and based on mainly single studies with very low-quality evidence. Additiona...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Gestational diabetes mellitus (GDM) affects approximately 1-24% of pregnancies [1]. It is defined as glucose intolerance that is recognized for the first time during pregnancy [2]. GDM is associated with adverse complications for the mother (pre-eclampsia, cesarean section) and the fetus (dystocia, large for gestational age, and macrosomia) [3-5]. Early prediction of GDM can lead to appropriate interventions such as lifestyle changes or pharmacological means to reduce adverse health impact. There is no standard agreed-upon screening protocol for GDM.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Tags: Review Source Type: research
Publication date: Available online 2 May 2019Source: Pharmacological ResearchAuthor(s): José Luiz de Brito Alves, Yohanna de Oliveira, Nara Nóbrega Crispim Carvalho, Raíssa Georgianna Silva Cavalcante, Marília Marques Pereira Lira, Luciana Caroline Paulino do Nascimento, Marciane Magnani, Hubert Vidal, Valdir de Andrade Braga, Evandro Leite de SouzaAbstractMaternal cardiometabolic disorders, such as gestational diabetes mellitus, pre-eclampsia, obesity, and dyslipidemia, are the most common conditions that predispose offspring to risk for future cardiometabolic diseases, needing appropriate ther...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Marjon E. Feenstra1†, Mirthe H. Schoots2†, Torsten Plösch1, Jelmer R. Prins1, Sicco A. Scherjon1, Albertus Timmer2, Harry van Goor2 and Sanne J. Gordijn1* 1Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 2Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Objective: Management of late fetal growth restriction (FGR) is limited to adequate fetal monitoring and optimal timing of delivery. The Disproportionate Intrauterine Growth Intervention ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Abstract We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable bowel syndrome and eating disorders. These diseases all have in common a sex-dimorphic prevalence, with women more frequently affected than men. The co-occurrence between these 5-HT-linked diseases suggests that they have common physiopathological mechanisms. In most 5-HT-linked diseases (except for anorexia nervosa and irritable bowel syndrome), a decrease in...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
Conclusionsin a multi-ethnic population, first-trimester fasting plasma glucose levels were not a better predictor of pregnancy complications than HbA1c. Further, an early HbA1c ≥ 5.8% (39.9 mmol/mol) threshold is already associated with an increased risk of macrosomia.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
More News: Databases & Libraries | Diabetes | Diabetes Mellitus | Endocrinology | Hormones | Men | Perinatology & Neonatology | Pre-eclampsia | Pregnancy | Reproduction Medicine | Study