Stents no better than drugs for many heart patients: U.S. study

Many patients with severe but stable heart disease who routinely undergo invasive procedures to clear and prop open clogged arteries would do as well by just taking medications and making lifestyle changes, U.S. researchers reported on Saturday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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CONCLUSIONS: Abnormally high ABI appears to be associated with an increased risk of a composite of CVD/all-cause mortality in suspected or established CVD patients but not in the general population. However, additional well-designed studies are required to support the current findings. PMID: 31814377 [PubMed - as supplied by publisher]
Source: International Angiology - Category: Cardiology Tags: Int Angiol Source Type: research
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Vincent M. Brandenburg, Alexander Schuh, Rafael KramannAccelerated and premature cardiovascular calcification is a hallmark of patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD). The presence and the amount of cardiovascular calcification are among the driving forces of increased morbidity and mortality in renal patients. Cardiovascular calcification occurs at different sites, including the cardiac valves—a location that is of particular importance for both the patient and the treating phy...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Publication date: Available online 10 December 2019Source: Canadian Journal of CardiologyAuthor(s): Laurie W. Geenen, Vivan J.M. Baggen, Annemien E. van den Bosch, Jannet A. Eindhoven, Robert M. Kauling, Judith A.A.E. Cuypers, Jolien W. Roos-Hesselink, Eric BoersmaAbstractBackgroundSingle high-sensitivity troponin T (hs-TnT) measurement is predictive of cardiac events in adults with congenital heart disease (ACHD). We aimed to study the prognostic value of serial hs-TnT measurements in stable ACHD patients.MethodsIn total, 602 consecutive ACHD patients were enrolled in this prospective study (2011-2013). Blood sampling was...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
True Bearing Diagnostics is now seeking $20 million-plus in new funding in its push toward regulatory approval.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
This study focused on the role of Ulinastatin (UTI) in the anti-oxidative stress and anti-inflammatory response of cardiomyocytes. H9c2 cells were divided into control group, ischemia-anoxic group (ischemic hypoxia group) and ischemia-anoxia + UTI group (UTI group). Cell morphology was observed by light microscopy, Cell staining, Western blotting, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) were conducted to research the effect of UTI on the nuclear factor-κB (NF-κB) signaling pathway. H9c2 cells in the ischemic hypoxia group showed hypertrophy and ir...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
-- Cholesterol tests, also known as lipid panels and profiles, are blood tests that measure the amount of cholesterol in your blood, says Mayo Clinic. As high cholesterol is a prime risk factor for heart disease, cholesterol tests are an important...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
This study aims to explore the relation between endothelial nitric oxide synthase (eNOS) single-nucleotide polymorphisms (SNPs) and the risk of coronary heart disease (CHD). Methods SNPstats (online software: http://bioinfo.iconcologia.net/SNPstats) was performed to test Hardy–Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted to screen the preferable interaction between eNOS SNPs and smoking. Results The frequency for the rs1799983-T allele was 31.1% in CHD patients, which was significantly higher than that of 19.8% in controls (P
Source: Coronary Artery Disease - Category: Cardiology Tags: Risk Factors Source Type: research
Publication date: Available online 9 December 2019Source: Life SciencesAuthor(s): Qi Wei, Yuzhen Tu, Lin Zuo, Jia Zhao, Zhongbao Chang, Yan Zou, Jizhe QiuAbstractAimsAtherosclerosis is a risk factor for coronary heart disease and cerebral infarction. Recent reports show decreased miR-345-3p in apolipoprotein-E deficient mice. Our study aimed to determine the biological activities of miR-345-3p in endothelial cells exposed to oxidized low-density lipoprotein (oxLDL).Main methodsHuman umbilical vein endothelial cells were transfected with miR-345-3p mimic and then exposed to oxLDL. Expression of miR-345-3p was assayed using ...
Source: Life Sciences - Category: Biology Source Type: research
Arrhythmogenic cardiomyopathy (ACM) is a familial heart disease, associated with ventricular arrhythmias, fibrofatty replacement of the myocardial mass and an increased risk of sudden cardiac death (SCD). Malignant ventricular arrhythmias and SCD largely occur in the pre-clinical phase of the disease, before overt structural changes occur. To prevent or interfere with ACM disease progression, more insight in mechanisms related to electrical instability are needed. Currently, numerous studies are focused on the link between cardiac arrhythmias and metabolic disease. In line with that, a potential role of mitochondrial dysfu...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractPersistent left-sided superior vena cava (PLSVC) is the commonest systemic venous anomaly in the thorax with a reported prevalence of up to 0.5% in otherwise normal population and up to 10% in patients with congenital heart disease (CHD). In the absence of associated CHD, it is usually asymptomatic, discovered incidentally. It may complicate catheter or pacemaker lead placement. PLSVC typically drains into the right atrium through the coronary sinus. In children with CHD, the presence of a PLSVC may affect the choice of certain surgical procedures. PLSVC is significantly more common in association with situs ambigu...
Source: La Radiologia Medica - Category: Radiology Source Type: research
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