GSE140435 Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory

Contributors : Seblewongel Asrat ; Navneet Kaur ; Xia Liu ; Li-Hong Ben ; Daisuke Kajimura ; Andrew J Murphy ; Matthew A Sleeman ; Andre Limnander ; Jamie M OrengoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSummary: Long-lived IgE plasma cells reside in the bone marrow of allergic mice and atopic humans, confer IgE serological memory and produce allergen-specific IgE that can drive anaphylaxis.Abstract: Immunoglobulin E (IgE) plays an important role in allergic diseases. Nevertheless, the source of IgE serological memory remains controversial. We re-examined the mechanism of serological memory in allergy using a dual-reporter system to track IgE plasma cells (PCs) in mice. Short-term allergen exposure resulted in the generation of IgE plasma cells that resided mainly in secondarylymphoid organs and produced IgE that was unable to degranulate mast cells. In contrast, chronic allergen exposure led to the generation of long-lived IgE plasma cells that were primarily derived from sequential class switching of IgG1, accumulated in the bone marrow (BM) and produced IgE capable of inducing anaphylaxis. Most importantly, IgE plasma cells were found in the BM of human allergic, but not non-allergic donors, and allergen-specific IgE produced by these cells was able to induce mast cell degranulation when transferred to mice. These data demonstrate that longlived IgE BMPCs arise during chronic allergen exposure and establish serological memory i...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

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Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
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Source: Immunology Letters - Category: Allergy & Immunology Authors: Tags: Immunol Lett Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Peanut allergy affects 1-2% of individuals in the United States, and is increasing in prevalence.1-4 Although there is accumulating data on immunotherapy for peanut allergy,5-8 the cornerstone of management remains strict avoidance of peanut protein, maintenance of an emergency action plan and prompt use of epinephrine to treat systemic reactions in case of an accidental exposure, which occurs in up to 12-15% of peanut-allergic individuals annually.9,10 Peanut allergy significantly impacts quality of life,11 as it is typically lifelong, is the leading cause of food-induced anaphylaxis in children, and the leading cause of ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
CONCLUSION: Proper workup after an intraoperative anaphylactic event has a fairly good chance of identifying the causative allergen. These results are useful for patient management and the planning of subsequent anaesthetic procedures. PMID: 31788702 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - Category: General Medicine Authors: Tags: Singapore Med J Source Type: research
Publication date: Available online 28 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Paul J. Turner, Dianne E. Campbell, Megan S. Motosue, Ronna L. CampbellAbstractThe true global scale of anaphylaxis remains elusive, because many episodes occur in the community without presentation to healthcare facilities, and most regions have not yet developed reliable systems with which to monitor severe allergic events. The most robust datasets currently available are based largely on hospital admissions, which are limited by inherent issues of misdiagnosis, misclassification and generaliza...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Authors: Scott LA, Jones BI, Berni TR, Berni ER, De Vries J, Currie CJ Abstract Aims: To describe the epidemiology of peanut allergy (PA) in the UK over the last three decades.Methods: PA patients were identified from the Clinical Practice Research Datalink between 1987 and 2015. Incidence and prevalence of PA were compared between 2000 and 2015. Prevalence and relative risk (RR) of atopic comorbidities, anaphylaxis, adrenaline prescriptions versus matched controls were calculated.Results: Point prevalence of PA in the entire population and those
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Publication date: Available online 27 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Didier G. Ebo, Brian A. Baldo, Athina L. Van Gasse, Christel Mertens, Jessy Elst, Luc Sermeus, Chris H. Bridts, Margo M. Hagendorens, Luc S. De Clerck, Vito Sabato
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Research Source Type: research
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