Molecules, Vol. 24, Pages 4140: Lunasin Improves the LDL-C Lowering Efficacy of Simvastatin via Inhibiting PCSK9 Expression in Hepatocytes and ApoE −/− Mice

Molecules, Vol. 24, Pages 4140: Lunasin Improves the LDL-C Lowering Efficacy of Simvastatin via Inhibiting PCSK9 Expression in Hepatocytes and ApoE−/− Mice Molecules doi: 10.3390/molecules24224140 Authors: Lili Gu Yaqin Gong Cheng Zhao Yue Wang Qinghua Tian Gaoxin Lei Yalin Liang Wenfeng Zhao Shuhua Tan Statins are the most popular therapeutic drugs to lower plasma low density lipoprotein cholesterol (LDL-C) synthesis by competitively inhibiting hydroxyl-3-methyl-glutaryl-CoA (HMG-CoA) reductase and up-regulating the hepatic low density lipoprotein receptor (LDLR). However, the concomitant up-regulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) by statin attenuates its cholesterol lowering efficacy. Lunasin, a soybean derived 43-amino acid polypeptide, has been previously shown to functionally enhance LDL uptake via down-regulating PCSK9 and up-regulating LDLR in hepatocytes and mice. Herein, we investigated the LDL-C lowering efficacy of simvastatin combined with lunasin. In HepG2 cells, after co-treatment with 1 μM simvastatin and 5 μM lunasin for 24 h, the up-regulation of PCSK9 by simvastatin was effectively counteracted by lunasin via down-regulating hepatocyte nuclear factor 1α (HNF-1α), and the functional LDL uptake was additively enhanced. Additionally, after combined therapy with simvastatin and lunasin for four weeks, ApoE−/− mice had significantly lower PCSK9 an...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research

Related Links:

To prevent heart problems later in life, people 45 and younger with higher levels of bad cholesterol might want to change their eating and exercise habits, or even talk to their doctor about medications such as statins, a new study says.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
The Pharmacogenomics Journal, Published online: 05 December 2019; doi:10.1038/s41397-019-0125-xStatin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
Researchers are using artificial intelligence to measure a common marker of heart disease via lung cancer screenings. The research was presented at the annual meeting of the Radiological Society of North America (RSNA). Low-dose chest CT is approved for lung cancer screening in high-risk people, such as long-time smokers. While these CT scans are intended to diagnose lung cancer, coronary artery calcium, a measure of plaque in the arteries, is also visible on CT. The coronary artery calcium score derived from CT is a well-established measure that helps doctors decide who should get cholesterol-lowering preventive medicatio...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health IVD Source Type: news
High cholesterol is known to be one of the primary risk factors for heart disease, since it can contribute to plaque buildup in the arteries. But even though the U.S. Centers for Disease Control and Prevention recommends regular cholesterol testing starting around age 20, many Americans don’t give cholesterol—or heart disease, for that matter—much thought until later in life. A new modeling study published in the Lancet gives extra reason not to put off cholesterol screening and treatment. It confirms that high blood levels of “bad” (or non-HDL) cholesterol are associated with a greater risk o...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
Understanding risks early on could help protect from disease later in life and ‘offer chance to take statins or adjust diet’All adults as young as 25, as well as older people, need to know of their “bad cholesterol” levels so they can change their lifestyle or take drugs to protect themselves against heart attacks or strokes in later life, say scientists.A landmark study involving data from nearly 400,000 people in 19 countries has established for the first time that levels of non-HDL, or “bad cholesterol”, in the blood are closely linked to the risk of heart disease across the entire li...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: UK news Health Heart attack Stroke Young people Older people Nutrition Science Obesity World news Source Type: news
Young doctors also prescribing to friends and family Related items fromOnMedica GPs need more time to treat complex needs GPs defend practice on prescribing statins Double check patients with ‘penicillin’ allergy to avoid MRSA risk Clinicians need better options if we are to stop over-medication MHRA tightens licence restrictions on valproate for women
Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionsOur findings showed that a large proportion of patients with SLE have a considerable cardiovascular risk and many of them would be eligible for statin therapy. However, the statin use observed was low.Key Points• A large proportion of patients with lupus have a considerable cardiovascular risk, explained in part by dyslipidemia.• Many patients with SLE would be eligible for statin therapy according to risk stratification based on conventional risk factors.• The use of statins in this population is inadequate.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 3 December 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Robert ScraggAbstractAccumulating evidence from observational studies indicates that vitamin D status is inversely associated with a many non-skeletal diseases. This has initiated the conduct of several large clinical trials to determine if high dose vitamin D supplementation (≥ 2000 IU/day or monthly equivalent) prevents non-skeletal disease including cardiovascular disease, cancer and mortality. One of these trials is the Vitamin D Assessment (ViDA) Study which recruited 5,110 participants, age...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Many clinical trials have demonstrated that statins convey protective effects against atherosclerosis independent of cholesterol-lowering capacities. Other evidence indicates that pyroptosis, a type of programmed cell death, is likely involved in atherosclerosis, but the effects and mechanisms of statins on pyroptosis must be further revealed.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
ConclusionsDuring the first year of availability, the rate of prescription of PCSK9 inhibitors appears below expectations. Patients were mainly in secondary prevention and had been slightly persistent to previous LLTs. During follow-up, the PCSK9 inhibitor monotherapy showed high levels of adherence and persistence. This real-world study sets the stage for future longer-term investigations useful to improve our knowledge on the appropriateness, drug access and public healthcare sustainability of PCSK9 inhibitors.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
More News: Chemistry | Cholesterol | Simvastatin | Statin Therapy | Zocor