Identification of miRNAs from stem cell derived microparticles in umbilical cord blood

Cord blood (CB) represents an alternative source of stem cells for hematopoietic stem cell transplantation (HSCT) [1]. Hematopoietic stem cells (HSC) express high number of the cell surface glycoprotein CD34+ which is associated with stem cell engraftment [1]. MPs represent a part of the extracellular vesicles with various size (100-1000nm) and content [2], released from cells during apoptosis or activation [3]. MPs are produced by budding from the plasma membrane after rearrangement of cytoskeleton which leads to the exposure of phosphatidylserine (PS) [4].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Brief Communication Source Type: research