FDA Panel Recommends High-Dose EPA for CV Event Reduction FDA Panel Recommends High-Dose EPA for CV Event Reduction

Icosapent ethyl (Vascepa, Amarin) was unanimously recommended for approval as an adjunct to statin therapy. However, the exact population for whom the drug should be prescribed was not decided.News Alerts
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Alert Source Type: news

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Discussion–conclusionThe findings of this study suggest that caution should be taken when prescribing Statins in older adults, as this could decrease ML stability and ultimately increase fall risk.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
We present normally distributed variables using means and standard deviations and non-normally distributed variables using medians along with their ranges. Spearman's correlation coefficients were used to analyse correlations between the CSF's biomarker concentrations, and both unadjusted and Bonferroni adjusted p-values are reported. Orthogonal projection to latent structure discriminant analysis (OPLS-DA) was also used to find differences in terms of CSF metabolites between the relapsing and remitting patients [CIS, RR, PR versus PP, SP patients]. The OPLS-DA algorithm finds the projection direction, score vector, that g...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
The Pharmacogenomics Journal, Published online: 06 December 2019; doi:10.1038/s41397-019-0136-7Genetic contribution to lipid target achievement with statin therapy: a prospective study
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
ConclusionsThere was a significant association between statin use and TUG inability in older Chinese inpatients with diabetes.
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
To prevent heart problems later in life, people 45 and younger with higher levels of bad cholesterol might want to change their eating and exercise habits, or even talk to their doctor about medications such as statins, a new study says.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Abstract Objective: To evaluate clinical associations of anti-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody (Ab) and statin exposure in necrotizing myopathy (NM) patients.Methods: NM without a known myositis-specific autoantibody (MSA) was ascertained from a large single-centre myositis database between 1985 and 2012. A comparison NM cohort included 32 anti-SRP+ autoantibody patients, and other control groups included 74 non-NM myositis patients and 21 non-myositis controls. Sera from all cases and controls were tested using a validated anti-HMGCR enzyme-linked immunosorbent assay. Clinical f...
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
The Pharmacogenomics Journal, Published online: 05 December 2019; doi:10.1038/s41397-019-0125-xStatin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
We present the case of a 44-year-old physician with familial heterozygous hypercholesterolemia who experienced multiple tendon ruptures during 19 years of statin therapy and no tendon injuries in the 5 years since statins were discontinued. Statins may deleteriously affect tendon extracellular matrix by inhibiting synthesis of matrix metalloproteinases and cell cycle regulatory proteins. Clinicians should be aware of this possible association between statins and tendinopathy.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Case Report Source Type: research
Researchers are using artificial intelligence to measure a common marker of heart disease via lung cancer screenings. The research was presented at the annual meeting of the Radiological Society of North America (RSNA). Low-dose chest CT is approved for lung cancer screening in high-risk people, such as long-time smokers. While these CT scans are intended to diagnose lung cancer, coronary artery calcium, a measure of plaque in the arteries, is also visible on CT. The coronary artery calcium score derived from CT is a well-established measure that helps doctors decide who should get cholesterol-lowering preventive medicatio...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health IVD Source Type: news
High cholesterol is known to be one of the primary risk factors for heart disease, since it can contribute to plaque buildup in the arteries. But even though the U.S. Centers for Disease Control and Prevention recommends regular cholesterol testing starting around age 20, many Americans don’t give cholesterol—or heart disease, for that matter—much thought until later in life. A new modeling study published in the Lancet gives extra reason not to put off cholesterol screening and treatment. It confirms that high blood levels of “bad” (or non-HDL) cholesterol are associated with a greater risk o...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
More News: Cardiology | Cholesterol | Heart | Statin Therapy