ASN: Encephalopathy Up in CKD Patients on Higher-Dose Baclofen

WEDNESDAY, Nov. 13, 2019 -- The incidence of encephalopathy is increased with prescription of higher versus lower doses of baclofen among older patients with chronic kidney disease (CKD), according to a study published online Nov. 9 in the Journal...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Authors: Vijayvergiya R, Kanabar K, Kaushal S, Lal A, Krishnan S Abstract A 42-year-old female with end-stage chronic kidney disease, who was on maintenance hemodialysis for the last 3 years, presented with facial and upper-limb swelling of 2-month duration. A computed tomography (CT) scan confirmed significant stenosis of the superior vena cava (SVC). Following discussion in a multidisciplinary meeting, it was proposed to perform a repeat endovascular intervention to relieve the SVC obstruction and manage the migrated stent. PMID: 32479419 [PubMed - in process]
Source: The Journal of Invasive Cardiology - Category: Cardiology Tags: J Invasive Cardiol Source Type: research
This randomized clinical trial compares the albuminuria-lowering effects of Roux-en-Y gastric bypass surgery vs best medical treatment in patients with early-stage chronic kidney disease, type 2 diabetes, and obesity.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
ConclusionWe observed an improvement in AKI patient survival over the years, even after correction for several confounders and using a competing risk approach. Identification of risk factors for mortality can help in decision-making for timely intervention, leading to better clinical outcomes.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsOur meta-analysis demonstrates that GLS is associated with all-cause mortality, MCE, cardiovascular mortality, and combined adverse events in CKD patients.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
It is well established that diabetes is the major cause of chronic kidney disease worldwide. Both hyperglycemia, and more recently, advanced glycation endproducts, have been shown to play critical roles in the development of kidney disease. Moreover, the renin-angiotensin system along with growth factors and cytokines have also been shown to contribute to the onset and progression of diabetic kidney disease; however, the role of lipids in this context is poorly characterized. The current study aimed to compare the effect of 20 weeks of streptozotocin-induced diabetes or western diet feeding on kidney disease in two differe...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Authors: Souza E, Cho KH, Harris ST, Flindt NR, Watt RK, Pai AB Abstract INTRODUCTION: The hypoxia-inducible factor prolyl hydroxylase (HIF-PH) pathway is responsible for regulating the biosynthesis of erythropoietin (EPO) and maintaining iron homeostasis. Investigational drugs that target the HIF-PH pathway are promising alternatives for treating anemia in Chronic Kidney Disease (CKD). Areas covered: This review summarizes recent advances focused on the clinical development of HIF-PH inhibitors (HIF-PHIs) as potentially novel therapies in the treatment of anemia in CKD based on publications available on PubMed and...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Condition:   Chronic Kidney Diseases Intervention:   Other: assessment of postural stability Sponsor:   Cairo University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Chronic Kidney Diseases Intervention:   Diagnostic Test: Albumin creatinine ratio Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Chronic Kidney Diseases;   Peritoneal Dialysis;   Hemodialysis Intervention:   Dietary Supplement: Curcumin supplementation Sponsor:   Universidade Federal Fluminense Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Chronic Kidney Diseases Intervention:   Other: assessment of postural stability Sponsor:   Cairo University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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