Sleep Disorders in Wilson ’s Disease

AbstractPurpose of ReviewWe aimed to review the sleep disorders described in Wilson ’s disease (WD), focusing on their mechanisms and treatments.Recent FindingsREM sleep behavior disorder or sleepiness can be warning signs of future WD. These early symptoms may significantly reduce the time to WD diagnosis. Early anti-copper therapies (chelators or zinc salts), reducing copper accumulation in the brain and though saving brain tissue, can allow the complete disappearance of these sleep disorders and of course improve the other symptoms of WD.SummaryInsomnia, restless legs syndrome (RLS), daytime sleepiness, cataplexy, and REM sleep behavior disorder (RBD) are present in WD and should be explored with video polysomnography and multiple sleep latency test. Suggested immobilization test could be useful in the diagnosis of RLS in WD. Motor and non-motor symptoms, dysautonomic dysfunctions, drugs, and lesions of the circuits regulating wake and sleep may be involved in the mechanisms of these sleep abnormalities. Adapted treatments should be proposed.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research

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AbstractRestless legs syndrome (RLS) is characterized by an urge to move legs, usually accompanied by uncomfortable sensations. RLS symptoms generally happen at night and can be relieved by movements. Genetic studies have linked polymorphisms inBTBD9 to a higher risk of RLS. Knockout ofBTBD9 homolog in mice (Btbd9) and fly results in RLS-like phenotypes. A dysfunctional dopaminergic system is associated with RLS. However, the function ofBTBD9 in the dopaminergic system and RLS is not clear. Here, we made use of the simpleCaenorhabditis elegans nervous system. Loss ofhpo-9, the worm homolog ofBTBD9, resulted in hyperactive ...
Source: Anatomy and Embryology - Category: Anatomy Source Type: research
AbstractPurpose of ReviewIn amyotrophic lateral sclerosis (ALS), sleep disruption is frequently present and substantially adds to disease burden. This review aims to summarize current knowledge on causes, pathophysiology, and treatment of sleep disturbances in ALS.Recent FindingsMotor neuron degeneration and muscle weakness may lead to muscle cramps, pain, spasticity, immobilization, restless legs, sleep-disordered breathing, and difficulties to clear secretions. Furthermore, existential fears and depression may promote insomnia. Sleep-disordered breathing, and nocturnal hypoventilation in particular, requires ventilatory ...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
PMID: 32449288 [PubMed - in process]
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
Publication date: Available online 22 May 2020Source: NeuroscienceAuthor(s): Shangru Lyu, Hong Xing, Mark P. DeAndrade, Pablo D. Perez, Fumiaki Yokoi, Marcelo Febo, Arthur S. Walters, Yuqing Li
Source: Neuroscience - Category: Neuroscience Source Type: research
ola Lanteri Restless legs syndrome is a common but still underdiagnosed neurologic disorder, characterized by peculiar symptoms typically occurring in the evening and at night, and resulting in sleep disruption and daily functioning impairment. This disease can affect subjects of all age ranges and of both sexes, manifesting itself with a broad spectrum of severity and deserving special attention in certain patient categories, in order to achieve a correct diagnosis and an effective treatment. The diagnosis of restless legs syndrome can be challenging in some patients, especially children and elderly people, and an eff...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Publication date: Available online 18 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Katie L.J. Cederberg, Brenda Jeng, Jeffer E. Sasaki, Robert W. Motl
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionThese results suggest that prevalence of RLS is associated with CAD and with CAD severity. We conjecture that RLS may be related to vascular endothelial dysfunction in cardiovascular disease.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
CONCLUSION: These results suggest that prevalence of RLS is associated with CAD and with CAD severity. We conjecture that RLS may be related to vascular endothelial dysfunction in cardiovascular disease. PMID: 32430676 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
Gerber Brand Persons with multiple sclerosis (PwMS) often complain about sleep problems. There is less known about objective sleep-electroencephalography (EEG) dimensions within naturalistic conditions (i.e., home and/or familiar setting). The present cross-sectional study examined the associations between objective and subjective sleep, depression, physical activity scores, and MS-related information among PwMS in their familiar setting. The sample consisted of 16 PwMS (mean age: 50.3 years; median Expanded Disability Status Scale (EDSS): 5.5) who completed questionnaires covering subjective sleep (symptoms of ins...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Journal of Clinical Sleep Medicine,Volume 16, Issue 5, Page 829-830, May 2020.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research
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