Peripheral quantitative computed tomography (pQCT) –based finite element analysis provides enhanced diagnostic performance in identifying non-vertebral fracture patients compared with dual-energy X-ray absorptiometry
ConclusionspQCT-FE modeling can provide enhanced diagnostic performance compared with DXA and, given its moderate cost, may be useful in clinical settings.
ConclusionsHU measurements in CT scans have proven to be a feasible tool to additionally assess bone quality at the lumbar and sacral spine with good sensitivity, when compared with the gold standard DXA.Level of evidenceIII.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material.
ConclusionsThe newly developed 3D MOI enables distinguishing women with osteoporosis from those with normal BMD with good sensitivity and specificity.Clinical relevanceWhenever a CBCT scan is performed for specific clinical indications, a 3D MOI may be performed to qualitatively and quantitatively assess the condition of the mandibular cortex. This may be surely helpful to assess the osteoporosis status in the ageing population and more specifically in peri- or postmenopausal women.
ConclusionsOur results suggest that hyperostosis of the posterior longitudinal ligament in OPLL may not be associated with bone strength and bone mineral status at the extremities.
CONCLUSION: The HUs derived from routine contrast-enhanced abdominal CT scans can be used for the evaluation of osteoporosis, without an additional radiation exposure and cost. PMID: 31731334 [PubMed - as supplied by publisher]
AbstractOsteoporosis is a metabolic bone disease with a high prevalence that affects the population worldwide, particularly the elderly. It is often due to fractures associated with bone fragility that the diagnosis of osteoporosis becomes clinically evident. However, early diagnosis would be necessary to initiate therapy and to prevent occurrence of further fractures, thus reducing morbidity and mortality. X-ray-based imaging plays a key role for fracture risk assessment and monitoring of osteoporosis. Whereas over decades dual-energy X-ray absorptiometry (DXA) has been the main method used and still reflects the referenc...
AbstractSummaryAssociations of current and previous physical activity (PA) with bone health are unclear. In postmenopausal women with low bone mineral density (BMD), current PA was positively associated with femoral neck BMD and microarchitecture. Past PA was positively associated with tibial microarchitecture. PA appears beneficial for bone health throughout the lifespan.IntroductionTo compare associations of current and past self-reported bone-specific physical activity, and current accelerometer-determined physical activity (PA), with bone structure (bone mineral density [BMD] and microarchitecture) in postmenopausal wo...
Conclusions: This study suggested that lower BMD and increased loss rate of BMD were associated with a higher risk of carotid calcification plaques in Chinese postmenopausal women. PMID: 31612731 [PubMed - as supplied by publisher]
Abstract We investigated the effects of ibandronate, a bisphosphonate; eldecalcitol, an active vitamin D3 analogue; and combination treatment with both agents on secondary osteoporosis and arthritis using rats with adjuvant-induced arthritis. Arthritis was induced in 8-week-old male Lewis rats. Rats were randomized into four treatment groups and an untreated normal control group: ibandronate, eldecalcitol, ibandronate + eldecalcitol, vehicle, and control. Paw thickness was measured to evaluate arthritis. Joint destruction was evaluated histomorphometrically by the ankle joint stained with Fast Green and safranin O...
Proximal junctional fractures (PJFr) can be a catastrophic complication associated with adult spinal deformity surgery. Presence of osteoporosis has been shown to be one of the risk factors for PJFr. Dural-Energy X-Ray Absorptiometry (DEXA) scans are standard screening tools for diagnosis of osteoporosis. However, spinal DEXA scores have been reported to be flawed with regional sclerosis associated with spinal degeneration representing a possible confounder to the study. Recently, investigators have reported on the use of a computed tomography (CT) scan surrogate in place of spinal DEXA scores.
Teriparatide has been used to improve bone quality when considering spinal fusion surgery in patients with osteoporosis. Hounsfield units (HU), a standardized measurement for radiodensity, can be obtained on routine computed tomography (CT) scans, while dual energy X-ray absorptiometry (DEXA) is the common test for bone density.