Epitopes as characterized by antibody-verified eplet mismatches determine risk of kidney transplant loss
To optimize strategies that mitigate the risk of graft loss associated with HLA incompatibility, we evaluated whether sequence defined HLA targets (eplets) that result in donor-specific antibodies are associated with transplant outcomes. To define this, we fit multivariable Cox proportional hazard models in a cohort of 118 382 United States first kidney transplant recipients to assess risk of death-censored graft failure by increments of ten antibody-verified eplet mismatches. To verify robustness of our findings, we conducted sensitivity analysis in this United States cohort and assessed the role of antibody-verified eplet mismatches as autonomous predictors of transplant glomerulopathy in an independent Canadian cohort.
Source: Kidney International - Category: Urology & Nephrology Authors: Ruth Sapir-Pichhadze, Xun Zhang, Abdelhakim Ferradji, Abeer Madbouly, Kathryn Tinckam, Howard Gebel, Daniel Blum, Marilyn Marrari, S Joseph Kim, Stephanie Fingerson, Pradeep Bashyal, H éloïse Cardinal, Bethany Foster Tags: Clinical Investigation Source Type: research
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