Burden of fungal infections in Morocco

Burden of fungal infections in MoroccoConference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Current suboptimal treatment options of invasive fungal infections and emerging resistance of the corresponding pathogens urge the need for alternative therapy strategies and require the identification of novel antifungal targets. Aspergillus fumigatus is the most common airborne opportunistic mold pathogen causing invasive and often fatal disease. Establishing a novel in vivo conditional gene expression system, we demonstrate that downregulation of the class 1 lysine deacetylase (KDAC) RpdA leads to avirulence of A. fumigatus in a murine model for pulmonary aspergillosis. The xylP promoter used has previously been shown t...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
We report the case of a 71 years old patient with chronic lymphocytic leukemia (CLL), who developed a rapidly progressing multi-fungal infection including mucormycosis of the central nervous system (CNS) during treatment with ibrutinib.On autopsy mucorales species were demonstrated intravascularly by histomorphology of several organs and lymph nodes and were characterized as Rhizomucor pusillus by polymerase-chain reaction (PCR) – analysis. In addition, invasive pulmonary Aspergillus fumigatus was found and also confirmed by PCR. To the best of our knowledge, this is the first confirmation of a multi-fungal sepsis an...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Publication date: Available online 28 November 2019Source: Microbiological ResearchAuthor(s): Sohini Chatterjee, Ranjan Ghosh, Narayan Chandra MandalAbstractFungal resistance against frequently used antifungal medicines used for invasive candidiasis and other fungal infections is directing scientist for searching and developing novel antifungal drugs. An endophytic fungal strain Alternaria tenuissima OE7 has been isolated from leaves of Ocimum tenuiflorum L. which showed antifungal activity against numbers of human pathogenic fungi including Trichophyton rubrum, Microsporum gypseum, Aspergillus parasiticus, A. flavus, A. f...
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
AbstractPurpose of ReviewThis review summarizes both the recent and relevant studies about the treatment of non-Aspergillus hyaline molds.Recent FindingsGiven the rarity of these infections, there have been no large randomized clinical trials regarding the most effective antifungal therapy.SummaryAlthough there are more data for the treatment ofFusarium andScedosporium, there are limited data with case reports that address the other rare hyalohyphomycetes. As we develop improved diagnostic techniques and larger fungal registries, we may be able to determine efficacious treatment modalities. We hope that future research wil...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Fungal infections have increased in the last few decades as a result of the use of broad-spectrum antibiotics and the growing number of immunocompromised patients (pts), which have led to changes in the saprophytic microorganisms usually isolated. Fungal empyema (FE) is still a rare entity, with a mortality rate of 70%. Retrospective analysis of fungal pleural effusions diagnosed in our hospital between 2015 and 2018. Aseptic sampling of pleural fluid was performed by thoracentesis, chest drainage (CT) or video-assisted thoracoscopic surgery (VATS). Seventeen fungal isolates were obtained from 15 pts (12 males, mean age 60...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Conclusion: Our results suggest high prevalence of positivity to GM in subjects with IPF. Moreover, these subjects showed a slight improvement in the functional trend with antifungal therapy. Further studies are needed to clarify the potential role of Aspergillus infection in IPF pathogenesis and progression.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Idiopathic interstitial pneumonias Source Type: research
The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in human cells makes this component an attractive target for antifungal development. The host environment and antifungal stress can lead to cell wall modifications related to drug resistance. Antifungals targeting the cell wall including the new β-D-glucan synthase inhibitor ibrexafungerp and glycosyl-phosphatidyl Inositol (GPI) anchor pathway inhibitor fosmanogepix are promising weapons against antifungal resistance. The fosmanogepix shows strong in vitro activity against the multidrug-resistant species Candida auris, Fusarium ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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