Fenoldopam mesylate for treating psoriasis: A new indication for an old drug

Publication date: Available online 9 November 2019Source: International Journal of PharmaceuticsAuthor(s): Sindhu Doppalapudi, Anjali Jain, Wahid Khan, Abraham J. DombAbstractFenoldopam, a highly selective dopamine receptor agonist, is available in clinics as Corlopam™ i.v. for the management of severe hypertension. Recent reports demonstrate its anti-proliferative activity in vitro in a dose dependent manner. However, stability issues of the drug due to its susceptibility to oxidation, pH sensitivity, poor transdermal flux, and the barrier properties of skin present challenges to develop a topical formulation of fenoldopam. The aim of the present study is to suggest a stable topical formulation of fenoldopam for the treatment of psoriasis. Water washable ointment and glycerin-based carbopol anhydrous gel of fenoldopam intended for topical delivery were prepared and evaluated in vitro and in vivo. Results from pH dependent stability studis suggest the necessity to maintain acidic pH in final formulations. The presence of an acidic adjuster in ointment and unneutralised carbopol dispersion of anhydrous gel maintain the desired acidic environment in the formulations. Stability studies of prepared formulations performed for 90 days indicate that the drug remains stable in formulations. In vivo studies demonstrate the applicability of the formulations for better skin penetration, skin compliance, and photosafety. Efficacy studies using an imiquimod induced psoriasis model c...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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In this study, the enhanced mice live somewhat longer than their unmodified peers, though not as much longer as is the case for the application of telomerase gene therapy. The mice do also exhibit reduced cancer risk, however. The scientists here class telomere shortening as a cause of aging, which is not a point universally agreed upon. Reductions in average telomere length in tissues looks much more like a downstream consequence of reduced stem cell activity than an independent mechanism. Researchers obtain the first mice born with hyper-long telomeres and show that it is possible to extend life without any geneti...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Researchers here provide evidence for periodontitis, gum disease, to contribute to hypertension, chronic raised blood pressure, via inflammatory mechanisms. Aggressively treating the periodontitis in hypertensive patients reduces both blood pressure and inflammatory markers. Periodontitis has previously been linked with a modestly increased risk of dementia, as well as increased cardiovascular mortality risk. In both cases, increased inflammation is strongly suspected to be the linking mechanism. Experimental and observational clinical evidence suggests a prominent role of inflammation in the development of hypert...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusions: It appears that further studies are necessary to explain this problem, perhaps to include an evaluation of TF levels in psoriatic skin. PMID: 31616219 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
This study aimed to extend previous research regarding the risk of psoriasis in children with asthma to an entire population subdivided by age.MethodsThe 2002 ‐2013 Korean Health Insurance Review and Assessment Service–National Sample Cohort (HIRA‐NSC) was used. The 167,693 participants with asthma were matched with 167,693 control participants for age, sex, income, region of residence, hypertension history, diabetes history, and dyslipidemia histor y. In both the asthma and control groups, the occurrences of asthma were investigated. The crude and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) f...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSIONS: The findings support the fact that psoriasis patients have a higher incidence of metabolic syndrome. Our study also recommends that psoriasis patients should be regularly monitored for metabolic syndrome complications and its associated risk factors such as hypertension, raised triglyceride, lowered HDL Cholesterol, increased fasting plasma glucose, and waist circumference. PMID: 31595859 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Conclusion: Patients with psoriasis expressing the C allele of AT1R1166 are susceptible to developing metabolic syndrome and have higher PASI scores as compared with patients carrying the A allele. PMID: 31571968 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
(Natural News) Scutellaria baicalensis, also known as Chinese skullcap, is a flowering plant used in traditional Chinese medicine. Its roots have been used since ancient times to treat various conditions, such as inflammation, hypertension, psoriasis, and respiratory infections. S. baicalensis contains many active components, the most widely studied of which are the flavonoids baicalin and baicalein. Baicalin has been shown to...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Psoriasis is a systemic inflammatory disease characterized by overproliferation of keratinocytes and epidermal thickening resulting from dysregulated immune responses.[1,2] This chronic condition, which affects approximately 1% to 4% of the world ’s population, is often associated with comorbidities, including obesity, type 2 diabetes, hyperlipidemia, hypertension, and cardiovascular disease.[3–7] The pathogenesis of psoriasis involves keratinocyte recruitment of myeloid dendritic cells, which produce interleukin (IL)-23 to activate T he lper 17 (Th17) cells.[2,8,9] Th17 cells, in turn, produce several cytokine...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
AbstractIntroductionPsoriasis is a systemic, chronic inflammatory disease that not only afflicts the skin but is also associated with cardiovascular disease and metabolic syndrome. The strongest susceptibility loci for the disease is within the human leukocyte antigen (HLA) complex, though specific HLA allelic associations vary between populations.ObjectiveOur objective was to investigate HLA associations with clinical phenotypes of psoriasis and metabolic syndrome in Chinese psoriasis cases.MethodsWe conducted an observational case –control study in Singapore with a cohort of psoriasis cases consecutively recruited ...
Source: Molecular Diagnosis and Therapy - Category: Molecular Biology Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31424569 [PubMed - as supplied by publisher]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
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