Cardiovascular Disease, Aging, and Clonal Hematopoiesis.

Cardiovascular Disease, Aging, and Clonal Hematopoiesis.
Annu Rev Pathol. 2019 Nov 05;:
Authors: Evans MA, Sano S, Walsh K
Abstract
Traditional risk factors are incompletely predictive of cardiovascular disease development, a leading cause of death in the elderly. Recent epidemiological studies have shown that human aging is associated with an increased frequency of somatic mutations in the hematopoietic system, which provide a competitive advantage to a mutant cell, thus allowing for its clonal expansion, a phenomenon known as clonal hematopoiesis. Unexpectedly, these mutations have been associated with a higher incidence of cardiovascular disease, suggesting a previously unrecognized connection between somatic mutations in hematopoietic cells and cardiovascular disease. Here, we provide an up-to-date review of clonal hematopoiesis and its association with aging and cardiovascular disease. We also give a detailed report of the experimental studies that have been instrumental in understanding the relationship between clonal hematopoiesis and cardiovascular disease and have shed light on the mechanisms by which hematopoietic somatic mutations contribute to disease pathology. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 15 is January 24, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 31689371 [PubMed - as supplied by pu...

Source: Annual Review of Pathology - November 4, 2019 Category: Pathology Authors: Evans MA, Sano S, Walsh K Tags: Annu Rev Pathol Source Type: research